Genome-wide association study investigating short and long sleep duration: a cross-population meta-analysis-猫眼课题宝

DOI：

10.1101/2022.09.09.22279703

发表时间：

2022-09

期刊：

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其他

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作者：

I. Austin-Zimmerman;D. Levey;O. Giannakopoulou;J. Deak;M. Galimberti;H. Zhou;Spiros C. Denaxas;H. Irizar;K. Kuchenbaecker;A. Mcquillin;the Million Veteran Program;J. Concato;Daniel J Buysse;J. Gaziano;D. Gottlieb;R. Polimanti;M. Stein;E. Bramon;J. Gelernter

睡眠持续时间与一系列负面健康结果和预期寿命缩短有关。我们对来自英国生物银行和百万退伍军人计划的欧洲、非洲、东亚和混合美国血统的成年人进行了短睡眠时间（少于6小时）和长睡眠时间（超过9小时）的全基因组关联研究。在一项跨人群荟萃分析中，我们确定了84个独立的短睡眠位点和1个长睡眠位点。我们使用cov-LDSC基于种群衍生连锁不平衡（LD）得分估计了每个祖先中两种睡眠特征的snp遗传力。我们确定了短睡眠和长睡眠特征之间的正遗传相关性（rg = 0.16; se=0.04； P=0.0002），以及与其他精神和心脏代谢表型相似的遗传相关性模式。孟德尔随机化揭示了短睡眠和抑郁之间的双向因果关系，长睡眠和抑郁之间的双向因果关系。

Sleep duration has been linked to a wide range of negative health outcomes and to reduced life expectancy. We conducted genome-wide association studies of short (less than 6 hours) and long (more than 9 hours) sleep duration in adults of European, African, East Asian, and admixed-American ancestry from UK Biobank and the Million Veteran Program. In a cross-population meta-analysis we identified 84 independent loci for short sleep and 1 for long sleep. We estimated SNP-based heritability for both sleep traits in each ancestry based on population derived linkage disequilibrium (LD) scores using cov-LDSC. We identified positive genetic correlation between short and long sleep traits (rg = 0.16; se=0.04; P=0.0002), as well as similar patterns of genetic correlation with other psychiatric and cardiometabolic phenotypes. Mendelian randomisation revealed a directional causal relationship between short sleep and depression, and a bidirectional causal relationship between long sleep and depression.

Genome-wide association study investigating short and long sleep duration: a cross-population meta-analysis

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