Molecular imaging of diabetes and diabetic complications: beyond pancreatic β-cell targeting
Molecular imaging of diabetes and diabetic complications: beyond pancreatic β-cell targeting
复制标题
糖尿病和糖尿病并发症的分子成像：超越胰腺β细胞靶向
DOI：
10.1016/j.addr.2018.11.007
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发表时间：
2019
影响因子：
16.1
通讯作者：
Zhaofei Liu
中科院分区：
文献类型：
--
作者：
Jichun Yang;Long Jiang Zhang;Fan Wang;Tianpei Hong;Zhaofei Liu
糖尿病是一种慢性非传染性疾病，影响全世界4亿多人。糖尿病患者是各种并发症的高风险，如心血管，肾脏和其他疾病。糖尿病（1型和2型糖尿病）的发病机制与胰腺β细胞的功能损伤有关。因此，大多数管理和预防糖尿病的努力都集中在保护β细胞及其功能上。成像技术的进步，如磁共振成像、磁共振波谱、正电子发射断层扫描和单光子发射计算机断层扫描，使得能够对体内β细胞的数量和功能进行无创和定量检测和表征。这些优点有助于确定和监测糖尿病的进展，并确定抗糖尿病治疗的疗效。除了β细胞靶向，与糖尿病发展相关的生物标志物的分子成像，例如，淋巴细胞浸润、胰岛炎和代谢变化也可能是早期检测糖尿病、监测其进展和并发症发生以及促进探索新的治疗干预的有前景的策略。此外，特定组织中葡萄糖摄取、产生和排泄的分子成像对于理解糖尿病的发病机制至关重要。本文综述了近年来非侵入性影像学技术在β细胞以外的生物标志物成像方面的研究进展，包括糖尿病的早期诊断、糖代谢的研究以及糖尿病并发症的精确诊断和监测，以更好地管理糖尿病患者。
Diabetes is a chronic non-communicable disease affecting over 400 million people worldwide. Diabetic patients are at a high risk of various complications, such as cardiovascular, renal, and other diseases. The pathogenesis of diabetes (both type 1 and type 2 diabetes) is associated with a functional impairment of pancreatic β-cells. Consequently, most efforts to manage and prevent diabetes have focused on preserving β-cells and their function. Advances in imaging techniques, such as magnetic resonance imaging, magnetic resonance spectroscopy, positron emission tomography, and single-photon-emission computed tomography, have enabled noninvasive and quantitative detection and characterization of the population and function of β-cellsin vivo. These advantages aid in defining and monitoring the progress of diabetes and determining the efficacy of anti-diabetic therapies. Beyond β-cell targeting, molecular imaging of biomarkers associated with the development of diabetes, e.g., lymphocyte infiltration, insulitis, and metabolic changes, may also be a promising strategy for early detection of diabetes, monitoring its progression, and occurrence of complications, as well as facilitating exploration of new therapeutic interventions. Moreover, molecular imaging of glucose uptake, production and excretion in specified tissues is critical for understanding the pathogenesis of diabetes. In the current review, we summarize and discuss recent advances in noninvasive imaging technologies for imaging of biomarkers beyond β-cells for early diagnosis of diabetes, investigation of glucose metabolism, and precise diagnosis and monitoring of diabetic complications for better management of diabetic patients.