Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes: a randomised controlled trial.
Time-restricted feeding improves blood glucose and insulin sensitivity in overweight patients with type 2 diabetes: a randomised controlled trial.
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限时喂养改善超重2型糖尿病患者的血糖和胰岛素敏感性：一项随机对照试验
DOI：
10.1186/s12986-021-00613-9
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发表时间：
2021-10-07
影响因子：
4.5
通讯作者：
Wu Z
中科院分区：
文献类型：
--
作者：
Che T;Yan C;Tian D;Zhang X;Liu X;Wu Z
限时喂养是一种新兴的饮食干预措施，越来越受欢迎。然而，尚无针对超重 2 型糖尿病患者进行限时喂养的随机临床试验。在这里，我们探讨了 12 周内限时喂养对超重 2 型糖尿病患者的血糖调节和体重变化的影响。患有 2 型糖尿病的超重成人 (n = 120) 按 1:1 随机分为两个饮食组：限时喂养组 (n = 60) 或对照组 (n = 60)。 60 名患者参加了为期 12 周的 10 小时限制进食治疗计划（8:00 至 18:00 随意进食；18:00 至 8:00 禁食）。 12 周内，与对照组相比，限时喂养组的血红蛋白 A1c 和体重有所下降（分别为 - 1.54%±0.19 和 - 2.98±0.43 kg）（p< 0.001）。与对照组相比，限时喂养组β细胞功能和胰岛素抵抗的稳态模型评估发生了变化（分别为0.73±0.21，p=0.005；-0.51±0.08，p=0.02）。限时喂养组的药效评分、SF-12评分以及甘油三酯、总胆固醇和低密度脂蛋白胆固醇水平均有所改善（− 0.66 ± 0.17，p = 0.006；5.92 ± 1.38，p < 0.001；相对于对照分别为- 0.23 ± 0.08 mmol/L，p = 0.03；- 0.32 ± 0.07 mmol/L，p = 0.01；- 0.42 ± 0.13 mmol/L，p = 0.02）组。两组之间的高密度脂蛋白胆固醇没有显着差异。这些结果表明，10小时限制进食可改善血糖和胰岛素敏感性，导致体重减轻，减少降糖药物的必要剂量并提高生活质量。它还可以通过降低动脉粥样硬化脂质水平来提供心血管益处。试验注册：本研究已在中国临床试验注册中心注册（ChiCTR-IPR-15006371）。在线版本包含可在 10.1186/s12986-021-00613-9 获取的补充材料。
Time-restricted feeding is an emerging dietary intervention that is becoming increasingly popular. There are, however, no randomised clinical trials of time-restricted feeding in overweight patients with type 2 diabetes. Here, we explored the effects of time-restricted feeding on glycaemic regulation and weight changes in overweight patients with type 2 diabetes over 12 weeks. Overweight adults with type 2 diabetes (n = 120) were randomised 1:1 to two diet groups: time-restricted feeding (n = 60) or control (n = 60). Sixty patients participated in a 10-h restricted feeding treatment program (ad libitum feeding from 8:00 to 18:00 h; fasting between 18:00 and 8:00 h) for 12 weeks. Haemoglobin A1c and body weight decreased in the time-restricted feeding group (− 1.54% ± 0.19 and − 2.98 ± 0.43 kg, respectively) relative to the control group over 12 weeks (p < 0.001). Homeostatic model assessment of β-cell function and insulin resistance changed in the time-restricted feeding group (0.73 ± 0.21, p = 0.005; − 0.51 ± 0.08, p = 0.02, respectively) compared with the control group. The medication effect score, SF-12 score, and the levels of triglycerides, total cholesterol and low-density lipoprotein cholesterol were improved in the time-restricted feeding group (− 0.66 ± 0.17, p = 0.006; 5.92 ± 1.38, p < 0.001; − 0.23 ± 0.08 mmol/L, p = 0.03; − 0.32 ± 0.07 mmol/L, p = 0.01; − 0.42 ± 0.13 mmol/L, p = 0.02, respectively) relative to the control group. High-density lipoprotein cholesterol was not significantly different between the two groups. These results suggest that 10-h restricted feeding improves blood glucose and insulin sensitivity, results in weight loss, reduces the necessary dosage of hypoglycaemic drugs and enhances quality of life. It can also offer cardiovascular benefits by reducing atherosclerotic lipid levels. Trial registration: This study was registered with the Chinese Clinical Trial Registry (ChiCTR-IPR-15006371). The online version contains supplementary material available at 10.1186/s12986-021-00613-9.