Variants in PDE11A and PDE1A are not associated with citalopram response.
Variants in PDE11A and PDE1A are not associated with citalopram response.
复制标题
PDE11A 和 PDE1A 的变异与西酞普兰反应无关。
DOI：
10.1038/sj.mp.4002074
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发表时间：
2007
影响因子：
11
通讯作者：
Hamilton,SP
中科院分区：
文献类型：
--
作者：
Teranishi,KS;Slager,SL;Garriock,H;Kraft,JB;Peters,EJ;Reinalda,MS;Jenkins,GD;McGrath,PJ;Hamilton,SP
最近，Wong 等人。 1 研究了墨西哥裔美国人中磷酸二酯酶 (PDE) 基因多态性与抗抑郁反应之间的关联。尽管缓解组和非缓解组的样本量有限，但两个单核苷酸多态性 (SNP) 与氟西汀或地昔帕明的缓解相关。报道的 PDE 基因 SNP 与抗抑郁药物缓解之间的关联需要使用更大的样本量进行进一步研究。我们试图在类似的种族群体中复制两个 SNP rs1549870 (PDE1A) 和 rs1880916 (PDE11A) 的反应表型数据，以进行 Wong 等人的非汇款人与汇款人分析。
Recently, Wong et al. 1 investigated an association between polymorphisms in phosphodiesterase (PDE) genes and antidepressant response in a Mexican-American population. Two single nucleotide polymorphisms (SNPs) were associated with remission in response to either fluoxetine or desipramine although sample sizes for remitter and nonremitter groups were of limited size. Association between the reported PDE gene SNPs and remission in response to antidepressants requires further investigation using larger sample sizes. We sought to replicate the response phenotype data for two SNPs, rs1549870 (PDE1A) and rs1880916 (PDE11A) in a similar ethnic group for the nonremitter vs remitter analysis in the Wong et al.