THE SEGMENT POLARITY GENE HEDGEHOG IS REQUIRED FOR PROGRESSION OF THE MORPHOGENETIC FURROW IN THE DEVELOPING DROSOPHILA EYE
THE SEGMENT POLARITY GENE HEDGEHOG IS REQUIRED FOR PROGRESSION OF THE MORPHOGENETIC FURROW IN THE DEVELOPING DROSOPHILA EYE
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DOI：
10.1016/0092-8674(93)90536-y
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发表时间：
1993-12-03
期刊：
影响因子：
64.5
通讯作者：
MOSES, K
中科院分区：
文献类型：
--
作者：
MA, CY;ZHOU, Y;MOSES, K
果蝇复眼的细胞类型分化始于形态发生沟。沟扫过发育中的眼上皮，并与四类细胞事件相一致：细胞形状的协调变化、基因表达的变化、细胞周期的同步以及单细胞创始细胞的规则排列。迄今为止，在发育中的眼睛中诱导这些事件的分子机制尚不清楚。我们在这里确定了一个沟发展所需要的基因，hedgehog （hh）。我们发现，hh在形态发生沟后的表达对其进展是连续需要的。我们认为hh蛋白的正向扩散诱导前细胞进入沟内。
Cell-type specification in the Drosophila compound eye begins at the morphogenetic furrow. The furrow sweeps across the developing eye epithelium and is coincident with four classes of cellular events: coordinated changes in cell shape, changes in gene expression, synchronization of the cell cycle, and the specification of a regular array of ommatidial founder cells. The molecular mechanisms that induce these events in the developing eye have hitherto been unknown. We identify here a gene specifically required for furrow progression, hedgehog (hh). We show that hh expression posterior to the morphogenetic furrow is continuously required for its progression. We propose that forward diffusion of hh protein induces anterior cells to enter the furrow.