System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes
System-wide Rewiring Underlies Behavioral Differences in Predatory and Bacterial-Feeding Nematodes
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DOI：
10.1016/j.cell.2012.12.013
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发表时间：
2013-01-17
期刊：
影响因子：
64.5
通讯作者：
Sommer, Ralf J.
中科院分区：
文献类型：
--
作者：
Bumbarger, Daniel J.;Riebesell, Metta;Sommer, Ralf J.
神经回路功能和突触连接模式之间的关系知之甚少，部分原因是缺乏更大的完整系统的比较数据。我们比较系统范围内的地图突触连接产生的串行透射电子显微镜的咽神经系统的两种线虫不同的摄食行为：微食线虫秀丽隐杆线虫和捕食线虫太平洋Pristionchus。我们发现了一个大规模的重新布线在一个复杂的系统中确定的神经元，所有这些都是同源的神经突解剖和细胞体的位置。比较图形理论分析揭示了一个惊人的模式，神经元布线与连接的复杂性增加，在前咽相关的牙齿样denellation，在口的形态特征。我们采用集中的中心性方法来确定神经元I1和I2的候选人调节捕食性喂养和预测的咽腺功能的实质性分歧。
The relationship between neural circuit function and patterns of synaptic connectivity is poorly understood, in part due to a lack of comparative data for larger complete systems. We compare system-wide maps of synaptic connectivity generated from serial transmission electron microscopy for the pharyngeal nervous systems of two nematodes with divergent feeding behavior: the microbivore Caenorhabditis elegans and the predatory nematode Pristionchus pacificus. We uncover a massive rewiring in a complex system of identified neurons, all of which are homologous based on neurite anatomy and cell body position. Comparative graph theoretical analysis reveals a striking pattern of neuronal wiring with increased connectional complexity in the anterior pharynx correlating with tooth-like denticles, a morphological feature in the mouth of P. pacificus. We apply focused centrality methods to identify neurons I1 and I2 as candidates for regulating predatory feeding and predict substantial divergence in the function of pharyngeal glands.