Cognitive decline is mediated by gray matter changes during middle age
Cognitive decline is mediated by gray matter changes during middle age
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DOI：
10.1016/j.neurobiolaging.2013.10.095
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发表时间：
2014-05-01
影响因子：
4.2
通讯作者：
Barroso, Jose
中科院分区：
文献类型：
--
作者：
Ferreira, Daniel;Molina, Yaiza;Barroso, Jose
阿尔茨海默病目前的理论框架提出，病理生理变化在痴呆诊断前10 - 20年就已发生。我们探讨了中年时期灰质的年龄相关变化如何影响认知表现这一问题。82名参与者（40 - 50岁，±2岁）接受了一套全面的神经心理学测试，涵盖了广泛的认知领域和成分。通过分层回归和自助法分析研究中介效应。结果显示，更易受影响的认知成分与执行功能相关，在较小程度上与加工速度相关。灰质的年龄相关差异主要涉及额叶。此外，视觉构造、视觉空间功能、反应时间、心理灵活性以及执行控制方面的年龄相关差异是由几个灰质区域介导的。增加对中年时期大脑变化对认知功能影响的了解非常重要。确定衰老过程的早期阶段可能有助于早期发现病理变化并进行治疗干预。（C）2014爱思唯尔公司。保留所有权利。
The present theoretical framework of Alzheimer's disease proposes that pathophysiological changes occur 10-20 years before the diagnosis of dementia. We addressed the question of how age-related changes in gray matter mediate the cognitive performance during middle age. Eighty-two participants (40-50 years, +/- 2) were assessed with a comprehensive neuropsychological battery covering a broad spectrum of cognitive domains and components. Mediation effects were studied with hierarchical regression and bootstrapping analysis. Results showed that more vulnerable cognitive components were related to executive functioning and in a lesser degree to processing speed. Age-related differences in gray matter mainly involved the frontal lobes. Moreover, age-related differences in visuoconstructive, visuospatial functions, reaction time, and mental flexibility and executive control were mediated by several gray matter regions. It is important to increase the knowledge of the impact of brain changes on cognitive function during middle age. To define the early stages of the aging process may allow early detection of pathologic changes and therapeutic interventions. (C) 2014 Elsevier Inc. All rights reserved.