The infectivity and pathogenicity of a group 2 bovine coronavirus in pups
The infectivity and pathogenicity of a group 2 bovine coronavirus in pups
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DOI：
10.1292/jvms.69.301
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发表时间：
2007-03-01
影响因子：
1.2
通讯作者：
Koyama, Hiroyuki
中科院分区：
文献类型：
--
作者：
Kaneshima, Takashi;Hohdatsu, Tsutomu;Koyama, Hiroyuki
犬呼吸道冠状病毒(CRCoV)与牛冠状病毒(BCOV)关系更为密切，最近在犬身上发现了CRCoV。在这项研究中，我们检查了BCOV是否能够感染和表现出对狗的致病性。将3只1月龄幼崽经口腔给予BCOV野毒分离株，并与2只对照动物一起饲养。结果，在挑战组和对照组的所有幼鼠中，证实了BCOV中和抗体效价的增加。此外，RT-PCR还在口腔和直肠拭子中检测到该病毒基因。这些结果表明，BCOV会感染狗，并且很容易感染其他饲养在一起的狗。但未观察到呼吸道症状、腹泻等临床症状。
Canine respiratory coronavirus (CRCoV), which is more closely related to the bovine coronavirus (BCoV), has recently been detected in dogs. In this study, we examined whether BCoV was capable of infecting and exhibiting pathogenicity in dogs. Three 1month-old pups were oronasally given field isolates of BCoV, and were kept together with 2 control animals. As a result, increases in BCoV-neutralizing antibody titers were confirmed in all pups in the challenged and control groups. Moreover, the virus gene was also detected in oral and rectal swabs by RT-PCR. These results indicate that BCoV infects dogs, and easily infects other dogs that are kept together. However, no clinical symptoms such as respiratory symptoms and diarrhea were observed.