Breast-feeding and maternal smoking in the etiology of Crohn's disease and ulcerative colitis in childhood.
Breast-feeding and maternal smoking in the etiology of Crohn's disease and ulcerative colitis in childhood.
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DOI：
10.1016/1047-2797(93)90066-d
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发表时间：
1993-07-01
影响因子：
5.6
通讯作者：
Trichopoulos, D
中科院分区：
文献类型：
--
作者：
Rigas, A;Rigas, B;Trichopoulos, D
摘录了纽约两家医院在五年期间(1986-1990)首次诊断为克罗恩病或溃疡性结肠炎的儿童或青少年患者的医疗记录，并记录了有关性别、年龄、种族、出生地、兄弟姐妹大小、出生顺序、母亲出生时年龄、出生月份、母乳喂养持续时间和母亲吸烟的信息。还提取了在炎症性肠病患者出现之前或之后立即出现在相应儿科消化内科的患者的医疗记录，以生成对照序列。对68例克罗恩病患者、39例溃疡性结肠炎患者和202例对照患者的资料进行多因素Logistic回归分析。母乳喂养与克罗恩病(P约0.04)和溃疡性结肠炎(P约0.07)呈负相关，相对危险点估计在0.5左右，并有证据表明这两种情况下都有持续时间相关的趋势。没有证据表明这两种疾病与母亲出生时的年龄、出生顺序、母亲吸烟或出生季节有关。
Medical records concerning pediatric or adolescent patients first diagnosed with Crohn's disease or ulcerative colitis in two New York hospitals during a 5-year period (1986 to 1990) were abstracted, and information concerning sex, age, race, birthplace, sibship size, birth order, maternal age at birth, month of birth, duration of breast-feeding, and maternal smoking was recorded. Medical records of patients presenting at the respective pediatric gastroenterology departments immediately before or after the patients with inflammatory bowel disease were seen were also abstracted in order to generate a control series. Data concerning 68 patients with Crohn's disease, 39 patients with ulcerative colitis, and 202 control patients were analyzed through multiple logistic regression. Breast-feeding was negatively associated with Crohn's disease (P approximately 0.04) and ulcerative colitis (P approximately 0.07), with relative risk point estimates around 0.5 and with evidence of duration-dependent trends in both instances. There was no evidence of association of either disease with maternal age at birth, birth order, maternal smoking, or season of birth.