Smoking and low antioxidant levels increase oxidative damage to sperm DNA
Smoking and low antioxidant levels increase oxidative damage to sperm DNA
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DOI：
10.1016/0027-5107(95)00251-0
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发表时间：
1996-04-13
影响因子：
2.3
通讯作者：
Ames, BN
中科院分区：
文献类型：
--
作者：
Fraga, CG;Motchnik, PA;Ames, BN
我们以前的研究表明，抗坏血酸摄入量低的男性精子DNA中的oxo（8）dG显著增加。由于香烟烟雾中的氧化剂含量高，会消耗血浆和组织中的抗氧化剂，因此在吸烟者和非吸烟者中测定了精子中的氧化DNA损伤以及精浆中的生育酚和抗坏血酸水平。与非吸烟者相比，吸烟者精子DNA中的oxo（8）dG（鸟嘌呤的氧化损伤）水平高出50%（p = 0.005）。吸烟者精浆中Cr-生育酚的浓度降低了32%（p = 0.03）。吸烟和低抗氧化剂水平会增加精子DNA的氧化损伤。我们讨论了父亲吸烟导致精子突变的可能性，这些突变会导致后代患癌症、出生缺陷和遗传疾病。
Our previous studies have shown that men with low ascorbate intake have markedly increased oxo(8)dG in the DNA of their sperm. Because cigarette smoke is high in oxidants and depletes plasma and tissue antioxidants, oxidative DNA damage in sperm and tocopherol and ascorbate levels in seminal plasma were determined in smokers and non-smokers. The level in sperm DNA of oxo(8)dG, an oxidative lesion of guanine, was 50% higher in smokers compared to non-smokers (p = 0.005). The concentration of cr-tocopherol in seminal plasma was decreased in smokers by 32% (p = 0.03). Smoking and low antioxidant levels increase oxidative damage to sperm DNA. We discuss the possibility that paternal smoking causes mutations in sperm that lead to cancer, birth defects, and genetic diseases in offspring.