Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice.
Climbing fibers encode a temporal-difference prediction error during cerebellar learning in mice.
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DOI：
10.1038/nn.4167
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发表时间：
2015-12
影响因子：
25
通讯作者：
Medina JF
中科院分区：
文献类型：
--
作者：
Ohmae S;Medina JF
攀爬纤维输入浦肯野细胞被认为通过产生驱动小脑学习的指导性信号来发挥教学作用。为了研究这些指导性信号是如何被编码的，我们记录了小鼠小脑依赖的眨眼条件反射过程中单个攀爬纤维的活动。我们的研究结果表明，攀爬纤维既发出了意外传递的信号，也发出了意外遗漏的信号，这是眨眼调节的指导性信号。此外，我们报告了令人惊讶的发现，如果这些刺激是新颖的，或者如果这些刺激预示着眼周气胀即将出现，那么由眼周气胀激活的攀爬纤维也会对来自其他感觉方式的刺激做出反应。这种攀爬纤维活动的模式与强化学习期间多巴胺神经元的反应惊人地相似，强化学习已被证明编码一种特殊类型的指导性信号，称为时间差异预测误差。
Climbing fiber inputs to Purkinje cells are thought to play a teaching role by generating the instructive signals that drive cerebellar learning. To investigate how these instructive signals are encoded, we recorded the activity of individual climbing fibers during cerebellar-dependent eyeblink conditioning in mice. Our findings show that climbing fibers signal both the unexpected delivery and the unexpected omission of the periocular airpuff that serves as the instructive signal for eyeblink conditioning. In addition, we report the surprising discovery that climbing fibers activated by periocular airpuffs also respond to stimuli from other sensory modalities, if those stimuli are novel or if they predict that the periocular airpuff is about to be presented. This pattern of climbing fiber activity is strikingly similar to the responses of dopamine neurons during reinforcement learning, which have been shown to encode a particular type of instructive signal known as a temporal difference prediction error.