Neural correlates of olfactory learning: Critical role of centrifugal neuromodulation
Neural correlates of olfactory learning: Critical role of centrifugal neuromodulation
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DOI：
10.1101/lm.941510
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发表时间：
2010-11-01
影响因子：
2
通讯作者：
Chen, Wei R.
中科院分区：
文献类型：
--
作者：
Fletcher, Max L.;Chen, Wei R.
哺乳动物的嗅觉系统因其经历经验依赖的可塑性的显著能力而被很好地建立。虽然这个过程涉及中央嗅觉通路的多个阶段的变化，但即使是处理的早期阶段，如嗅球和梨状皮质，也可以显示出高度的可塑性。就像在其他感觉系统中一样，这种可塑性可以由参与注意力和学习过程的大脑区域的离心式输入来控制。具体地说，鳞茎和皮质都接受胆碱能、去甲肾上腺素和5-羟色胺能调节系统的大量输入。这些神经调节剂通过作用于两个区域的抑制性局部中间神经元和输出神经元，对气味处理和气味记忆都有深远的影响。
The mammalian olfactory system is well established for its remarkable capability of undergoing experience-dependent plasticity. Although this process involves changes at multiple stages throughout the central olfactory pathway, even the early stages of processing, such as the olfactory bulb and piriform cortex, can display a high degree of plasticity. As in other sensory systems, this plasticity can be controlled by centrifugal inputs from brain regions known to be involved in attention and learning processes. Specifically, both the bulb and cortex receive heavy inputs from cholinergic, noradrenergic, and serotonergic modulatory systems. These neuromodulators are shown to have profound effects on both odor processing and odor memory by acting on both inhibitory local interneurons and output neurons in both regions.