Abelson virus-induced lymphomagenesis in mice.
Abelson virus-induced lymphomagenesis in mice.
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DOI：
10.1084/jem.148.3.714
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发表时间：
1978-09-01
期刊：
影响因子：
--
通讯作者：
Rowe WP
中科院分区：
文献类型：
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作者：
Risser R;Potter M;Rowe WP
从我们对小鼠中Abelson病毒（MuLV-A）淋巴瘤发生的研究中出现的突出事实是淋巴瘤诱导是（a）年龄依赖性的，（B）病毒剂量依赖性的，和（c）在与已知控制鼠白血病的其他基因无关的宿主基因的控制下（例如，Fv-2上的Fv-1）。在16株供试菌株中，只有BALB/c及其部分衍生株表现出较高的敏感性。对CXB重组近交系及其杂交小鼠的研究表明，BALB/c小鼠在Av-1和Av-2两个位点上携带显性敏感等位基因，这两个位点赋予这些小鼠对MuLV-A淋巴瘤诱导的部分易感性。此外，H-2可能在确定小鼠对MuLV-A的易感性方面起次要作用，其作用仅见于Av-1和Av-2抗性纯合子小鼠中。病毒学研究表明，成年B6小鼠的抗性与辅助病毒复制的限制无关，而是特异于缺陷转化病毒基因组。
The salient facts which have emerged from our study of Abelson virus (MuLV-A)lymphomagenesis in mice are that lymphoma induction is (a) age dependent, (b) virus dose dependent, and (c) under the control of host genes unrelated to other genes known to control murine leukemia (e.g., Fv-1 on Fv-2). Of 16 strains tested, only BALB/c and some of its derivative strains showed high sensitivity. Studies from CXB recombinant inbred strains and hybrids between them are interpreted to indicate that BALB/c carries dominant sensitivity alleles at two loci, tentatively designated Av-1 and Av-2, which conferon these mice partial susceptibility to MuLV-A lymphoma induction. In addition, H-2 may play a minor role in determining the susceptibility of mice to MuLV-A, its effect being seen only in mice homozygous for resistance at both Av-1 and Av-2. Virologic studies indicate that the resistance of adult B6 mice is not related to restriction on the helper virus replication, but is specific for the defective transforming virus genome.