IMPROVEMENT OF OLFACTORY FUNCTION AFTER SINUS SURGERY CORRELATES WITH WHITE MATTER PROPERTIES MEASURED BY DIFFUSION TENSOR IMAGING
IMPROVEMENT OF OLFACTORY FUNCTION AFTER SINUS SURGERY CORRELATES WITH WHITE MATTER PROPERTIES MEASURED BY DIFFUSION TENSOR IMAGING
复制标题
DOI：
10.1016/j.neuroscience.2017.07.070
复制
发表时间：
2017-09-30
期刊：
影响因子：
3.3
通讯作者：
Bitter, Thomas
中科院分区：
文献类型：
--
作者：
Guellmar, Daniel;Seeliger, Tabea;Bitter, Thomas
嗅觉受损与嗅球和皮质嗅区灰质的体积减少有关。另一方面，嗅觉受损的修复会导致这些区域容量的恢复。研究大脑白质类似变化的研究几乎是不存在的。因此，这项前瞻性研究的目的是使用磁共振扩散张量成像(DTI)来研究大脑白质。31例(54+/-13岁)嗅觉受损(慢性鼻窦炎)患者接受功能性鼻内窥镜手术(FESS)。分别于术前和术后3个月采集磁共振成像(MRI)数据。术前和术后进行嗅觉测试以评估嗅觉阈值、辨别和辨别(TDI)评分。术后TDI较术前显著提高9.06±8.81分。随后形成两组--一组有相关的术后嗅觉增加(Delta TDI>；=10分，12例患者)，另一组没有增加(Delta TDI<；10分，19例患者)。左侧扣带前皮质和右侧杏仁核的DTI参数与TDI评分呈显著正相关。嗅觉改善组右侧海马区和左侧颞下沟下白质的各向异性分数和表观弥散系数值较高。束特异性扩散特性分析显示，扣带回皮质与脾周围皮质的空间关系存在显著的组间差异。总体而言，这项前瞻性研究表明术后嗅觉恢复后脑白质结构发生了变化。(C)2017年IBRO。爱思唯尔有限公司出版。保留所有权利。
Impaired olfaction is associated with a volume decrease in the olfactory bulb as well as in the gray matter of cortical olfactory areas. On the other hand, restitution of an impaired olfaction results in a regain of volume in these regions. Studies investigating similar changes in the cerebral white matter are virtually not existent. The aim of this prospective study therefore was to investigate cerebral white matter using magnetic resonance diffusion tensor imaging (DTI). 31 patients (54 +/- 13 years) with olfactory impairment (chronic rhinosinusitis) and planned functional endoscopic sinus surgery (FESS) were included. Magnetic resonance imaging (MRI) data sets were acquired pre-operatively and 3 months after surgery. Pre- and postoperative olfactory testing was performed to assess the olfactory threshold, discrimination, and identification (TDI) score. A significant postoperative TDI improvement by 9.06 +/- 8.81 points was observed. Two groups were subsequently formed - one with relevant postoperative olfactory gain (Delta TDI >= 10 points, 12 patients) and one without gain (Delta TDI < 10 points, 19 patients). DTI parameter showed a significant correlation with the TDI score in the left anterior cingulate cortex and the right amygdala. In the group with relevant olfactory improvement higher values of fractional anisotropy and apparent diffusion coefficient were found in the right parahippocampal area and in the white matter below the left inferior temporal sulcus. Tract-specific diffusion property analysis revealed significant group differences in the cingulate cortex in spatial relationship to the perisplenial cortex. Overall, this prospective study indicates structural changes in white matter after postoperative restoration of olfaction. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.