Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity.
Staphylococcus aureus as an infectious agent: overview of biochemistry and molecular genetics of its pathogenicity.
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DOI：
10.18388/abp.2009_2491
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发表时间：
2009
影响因子：
1.7
通讯作者：
Konrad B. Plata;A. Rosato;G. Węgrzyn
中科院分区：
文献类型：
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作者：
Konrad B. Plata;A. Rosato;G. Węgrzyn
虽然据估计，一般人群中有20-30%是金黄色葡萄球菌的携带者，但这种细菌是导致医疗保健相关感染的最重要病原体之一。耐甲氧西林的S.金黄色葡萄球菌（MRSA）菌株产生了严重的治疗问题。对S.金黄色葡萄球菌感染似乎有必要开发针对该病原体的新的有效疗法。本文就沙门氏菌致病性的生化和遗传机制作一综述。金黄色葡萄球菌毒力因子，组织的基因组和参与毒力的基因的表达调控，以及导致甲氧西林耐药的机制，并简要讨论。
Although it is estimated that 20-30% of the general human population are carriers of Staphylococcus aureus, this bacterium is one of the most important etiological agents responsible for healthcare-associated infections. The appearance of methicillin resistant S. aureus (MRSA) strains has created serious therapeutical problems. Detailed understanding of the mechanisms of S. aureus infections seems necessary to develop new effective therapies against this pathogen. In this article, we present an overview of the biochemical and genetic mechanisms of pathogenicity of S. aureus strains. Virulence factors, organization of the genome and regulation of expression of genes involved in virulence, and mechanisms leading to methicilin resistance are presented and briefly discussed.