Development of a handheld Raman microspectrometer for clinical dermatologic applications
Development of a handheld Raman microspectrometer for clinical dermatologic applications
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DOI：
10.1364/oe.15.011874
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发表时间：
2007-09-17
期刊：
影响因子：
3.8
通讯作者：
Mahadevan-Jansen, Anita
中科院分区：
文献类型：
--
作者：
Lieber, Chad A.;Mahadevan-Jansen, Anita
Although skin is easily accessible to optical methodologies, a portable measurement head is necessary to allow ready spectroscopic interrogation of all anatomic locations. However, most conventional Raman microspectrometers and even dermatologic-specific Raman systems are fixed systems ill-suited to anatomic accessibility. To this end, we have developed a portable Raman microspectrometer system for future dermatologic studies. An in-house-built bench-top system was used to qualify the optical components and design. Based on this system's layout, a handheld microspectrometer was developed for future clinical application. This system produces similar operating characteristics to the bench-top prototype, and is shown to provide clear Raman spectra from skin tissue measured in vivo in clinically-feasible integration times. (C) 2007 Optical Society of America.
