Neuronal activity evoked in the inferior colliculus of the cat by surface macroelectrodes and penetrating microelectrodes implanted in the cochlear nucleus.
Neuronal activity evoked in the inferior colliculus of the cat by surface macroelectrodes and penetrating microelectrodes implanted in the cochlear nucleus.
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DOI：
10.1109/tbme.2010.2046169
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发表时间：
2010-07
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缺乏功能性听觉神经的人不能从人工耳蜗植入中受益，但听觉脑干植入（ABI）利用耳蜗核（CN）附近或耳蜗核上的刺激电极可以恢复一些听力。我们正在调查的可行性，补充这些表面电极与穿透微刺激电极内的腹CN（VCN），以及如何两种类型的电极可以协同使用。用表面电极和微电极记录了5只猫VCN电刺激下丘（ICC）诱发的多单位神经元反应。这些发现与接受表面电极和微电极ABI的II型神经纤维瘤病患者的结果一致。患者描述从他们的微电极感知比从他们的表面电极更类似于纯音，与猫的VCN中微电极的更大的音调选择性一致。此外，患者描述的感知从他们的表面电极的声音比那些从微电极，而在猫中，由表面电极诱发的ICC的神经元活动往往更大。这种一致性有助于验证我们的猫模型作为研究表面电极和穿透电极在临床ABI中协同使用的一种手段。
Persons lacking functional auditory nerves cannot benefit from cochlear implants, but an auditory brainstem implant (ABI) utilizing stimulating electrodes adjacent to or on their cochlear nucleus (CN) can restore some hearing. We are investigating the feasibility of supplementing these surface electrodes with penetrating microstimulating electrodes within the ventral CN (VCN), and how the two types of electrodes can be used synergistically. Multiunit neuronal responses evoked by VCN electrical stimulation with surface electrodes and microelectrodes were recorded in the inferior colliculus (ICC) of five cats. The findings are consistent with those from patients with type II neurofibromatosis who received ABIs with both surface and microelectrodes. The patients described percepts from their microelectrodes as more similar to pure tones than those from their surface electrodes, consistent with the greater tonotopic selectivity of microelectrodes in the cats’ VCN. Also, the patients describe percepts from their surface electrodes as louder than those from the microelectrodes, while in the cat, the neuronal activity evoked in the ICC by the surface electrodes tended to be greater. This concordance helps to validate our cat model as a means of investigating the synergistic use of surface and penetrating electrodes in a clinical ABI.