One-step polymer surface modification for minimizing drug, protein, and DNA adsorption in microanalytical systems
One-step polymer surface modification for minimizing drug, protein, and DNA adsorption in microanalytical systems
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DOI：
10.1039/c2lc40750g
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发表时间：
2013-01-01
期刊：
影响因子：
6.1
通讯作者：
Larsen, Niels B.
中科院分区：
文献类型：
--
作者：
Larsen, Esben Kjaer Unmack;Larsen, Niels B.
溶解分析物的非特异性吸附严重降低了聚合物微分析系统的灵敏度和可靠性。在这里，一步水相过程修饰聚合物材料表面，以强烈减少其对广泛的有机分析物的非特异性吸附，包括疏水和亲水药物（0.23 < ClogP < 8.95），小蛋白和大蛋白（胰岛素，白蛋白，IgG）和DNA。该涂层甚至限制了高度疏水性药物（ClogP）的吸附。8)在其药学相关浓度范围内
The non-specific adsorption of dissolved analytes strongly reduces the sensitivity and reliability in polymer microanalytical systems. Here, a one-step aqueous phase procedure modifies polymer material surfaces to strongly reduce their non-specific adsorption of a broad range of organic analytes including hydrophobic and hydrophilic drugs (0.23 < ClogP < 8.95), small and large proteins (insulin, albumin, IgG), and DNA. The coating is shown to limit the adsorption of even highly hydrophobic drugs (ClogP. 8) in their pharmaceutically relevant concentration range