Relative Importance of Central and Peripheral Adiposities on Cardiometabolic Variables in Females: A Japanese Population-Based Study
Relative Importance of Central and Peripheral Adiposities on Cardiometabolic Variables in Females: A Japanese Population-Based Study
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DOI：
10.1016/j.jocd.2016.04.004
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发表时间：
2017-01-01
影响因子：
2.5
通讯作者：
Yoneshima, Hideo
中科院分区：
文献类型：
--
作者：
Kouda, Katsuyasu;Dongmei, Namiraa;Yoneshima, Hideo
在流行病学研究中，关于中心性肥胖和外周性肥胖对心脏代谢危险因素的相对影响的证据很少，特别是在亚洲人群中。本研究采用日本女性人群研究数据，调查了中心-外周脂肪比与心脏代谢变量之间的相关性。源人群由1800名年龄在50岁或以上的女性组成，这些女性在日本基于人群的骨质疏松队列研究的第15 - 16年随访调查中。本研究分析了998名妇女的横断面数据，这些妇女根据双能X线吸收法获得了有关体脂变量、心脏代谢变量和潜在混杂因素的完整信息。在调整潜在混杂因素前后，躯干-肩胛脂肪比与臂踝脉搏波速度、血脂和血红蛋白A1 c水平均显示出显著相关性（p < 0.05）。脂肪比例和心脏代谢变量之间的关系是独立的脂肪体积（全身或躯干）和心脏代谢变量之间的关系。此外，在全身脂肪含量最低的三分位数女性中观察到躯干与四肢脂肪比率与心脏代谢变量之间的关系（分别为臂踝脉搏波速度，β = 0.08;高密度脂蛋白胆固醇，β = -0.32;低密度脂蛋白胆固醇，β = 0.15;血红蛋白A1 C，β = 0.16; p < 0.05）。中心性肥胖比外周性肥胖与心脏代谢变量更相关。关于中心-外周脂肪比的信息对于评价相对较瘦的日本女性特别有价值。
In epidemiological studies, there is little evidence regarding the relative impact of central adiposity and peripheral adiposity on cardiometabolic risk factors, especially in Asian populations. This study investigated associations between central-to-peripheral fat ratios and cardiometabolic variables using data from a population based study of Japanese women. The source population was composed of 1800 women aged 50 yr or older at the 15th- to 16th-yr follow-up survey of the Japanese Population-Based Osteoporosis Cohort Study. This study analyzed cross-sectional data from 998 women for whom complete information about body fat variables according to dual-energy X-ray absorptiometry, cardiometabolic variables, and potential confounding factors was available. Both before and after adjusting for potential confounding factors, trunk-to-appendicular fat ratios showed significant (p < 0.05) correlations with brachial ankle pulse wave velocity, serum lipids, and hemoglobin A1c levels. Relationships between fat ratios and cardiometabolic variables were independent of relationships between fat volumes (in whole body or in trunk) and cardiometabolic variables. Furthermore, relationships between trunk-to-appendicular fat ratios and cardiometabolic variables were observed among women in the lowest tertile of total body fat (brachial ankle pulse wave velocity, beta = 0.08; high-density lipoprotein cholesterol, beta = -0.32; low-density lipoprotein cholesterol, beta = 0.15; and hemoglobin A1C, beta = 0.16; p < 0.05, respectively). Central adiposity is more related to cardiometabolic variables than peripheral adiposity. Information on central-to-peripheral fat ratios is particularly valuable for the evaluation of relatively thin Japanese women.