T-Cell Signaling Regulated by the Tec Family Kinase, Itk
T-Cell Signaling Regulated by the Tec Family Kinase, Itk
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DOI：
10.1101/cshperspect.a002287
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发表时间：
2010-07-01
影响因子：
7.2
通讯作者：
Berg, Leslie J.
中科院分区：
文献类型：
--
作者：
Andreotti, Amy H.;Schwartzberg, Pamela L.;Berg, Leslie J.
Tec家族酪氨酸激酶调节淋巴细胞发育、活化和分化。在T细胞中，主要的Tec激酶是Itk，其在T细胞受体的下游起作用以调节磷脂酶C-γ。本文综述了Itk激酶结构和酶促调控的最新进展，重点是Itk蛋白结构域的相互作用和底物识别机制。我们还讨论了传统与先天性T细胞谱系，包括α-β和γ-δ T细胞亚群的发展中的作用。最后，我们描述了Itk信号在效应T细胞分化和细胞因子基因表达调控中的复杂作用。总之，这些数据暗示Itk是T细胞信号传导和功能的重要调节剂。
The Tec family tyrosine kinases regulate lymphocyte development, activation, and differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of the T-cell receptor to regulate phospholipase C-gamma. This review highlights recent advances in our understanding of Itk kinase structure and enzymatic regulation, focusing on Itk protein domain interactions and mechanisms of substrate recognition. We also discuss the role of Itk in the development of conventional versus innate T-cell lineages, including both alpha beta and gamma delta T-cell subsets. Finally, we describe the complex role of Itk signaling in effector T-cell differentiation and the regulation of cytokine gene expression. Together, these data implicate Itk as an important modulator of T-cell signaling and function.