PALATAL MUCOSA UNDER DENTURES - A QUALITATIVE HISTOLOGIC AND HISTOCHEMICAL ANALYSIS
PALATAL MUCOSA UNDER DENTURES - A QUALITATIVE HISTOLOGIC AND HISTOCHEMICAL ANALYSIS
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DOI：
10.1016/0022-3913(86)90424-5
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发表时间：
1986-11-01
影响因子：
4.6
通讯作者：
MIRZA, FD
中科院分区：
文献类型：
--
作者：
SHARMA, AK;MIRZA, FD
这些上皮和结缔组织的组织学观察结果与许多早期工作者的结果非常一致。其显著特征是由于组成细胞层的增加，上皮厚度增加，但角化减少，角蛋白主要是角化不全的种类。在应力区域中，胶原纤维网络有一定的减少，其中纤维呈现与正常波浪图案相反的不规则排列。还可见明显的慢性炎性渗出物。义齿下结缔组织的组织化学研究显示，存在高度弹性和抗性的oxytalan纤维网络，特别是在胶原纤维减少的区域。因此，义齿下的结缔组织反应与预期形成鲜明对比。结缔组织的这种异常行为可能是对上皮细胞变化的反应。由于角化减少，高度抵抗和保护层，结缔组织表现出改变的代谢和功能。我们假设结缔组织在保护和吸收压力方面起着更主导的作用，而这一作用迄今为止一直由上皮细胞承担。因此，防止义齿对结缔组织施加的应力到达可能导致再吸收的骨。因此，我们认为义齿磨损不仅会导致上皮细胞的变化，而且会导致结缔组织同样显著的反应。这种反应导致出现高抗性和弹性的Oxytalan纤维系统，其有助于结缔组织成功地对施加在其上的应力作出反应。
These histologic observations of the epithelium and connective tissue are in close agreement with a host of earlier workers. The striking feature is an increase in thickness of epithelium due to an increase in constituent cell layers, but a decrease in keratinization, with keratin mainly of the parakeratinized variety. There is a definite reduction of collagen fiber network in regions of stress where the fibers present an irregular arrangement in contrast to the normal wavy pattern. Marked chronic inflammatory exudate is also seen. Histochemical investigation of the connective tissue under dentures revealed the presence of a highly elastic and resistant oxytalan fiber network, especially in regions that showed a reduction in collagen fibers. Thus the connective tissue response under dentures is in sharp contrast to what is expected. This abnormal behavior of the connective tissue is probably a reaction to the changes in epithelium. As a result of reduction in keratinization, a highly resistant and protective layer, the connective tissue exhibits altered metabolism and function. We hypothesize that connective tissue takes up a more dominant role of protection and absorption of stress, a role hitherto fulfilled by the epithelium. Thus stresses exerted by dentures on connective tissues are prevented from reaching the bone where they could cause resorption. We therefore feel that denture wear not only results in change within the epithelium, but in an equally significant reaction of the connective tissue. This reaction results in the appearance of a highly resistant and elastic oxytalan fiber system, which assists the connective tissue to react successfully to the stresses exerted on it.