Interleukin 2 upregulates expression of its receptor on a T cell clone.
Interleukin 2 upregulates expression of its receptor on a T cell clone.
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DOI：
10.1084/jem.161.6.1575
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发表时间：
1985-06-01
影响因子：
15.3
通讯作者：
Ashwell, J D
中科院分区：
文献类型：
--
作者：
Malek, T R;Ashwell, J D
用白细胞介素2（IL-2）刺激II类限制性抗原特异性T细胞克隆导致细胞表面IL-2受体（IL-2-R）和细胞质IL-2-R信使RNA（mRNA）均显著增加，而未观察到Thy-1和L3 T4抗原的细胞表面表达增加，仅观察到Thy-1 mRNA适度增加。这些实验证明，在初始获得IL-2-R后，IL-2以及抗原能够直接上调IL-2-R mRNA和细胞表面IL-2- R分子的水平。
Stimulation of a class II-restricted, antigen-specific T cell clone with interleukin 2 (IL-2) resulted in substantial increases in both cell surface IL-2 receptor (IL-2-R) and cytoplasmic IL-2-R messenger RNA (mRNA), whereas no increase was observed for cell-surface expression of Thy-1 and L3T4 antigens, and only a modest increase in Thy-1 mRNA was observed. These experiments demonstrate that, after initial acquisition of the IL-2-R, IL-2 as well as antigen is able to directly upregulate both the level of IL-2-R mRNA and cell surface IL-2- R molecules.