Genetic Evidence for Recent Population Mixture in India
Genetic Evidence for Recent Population Mixture in India
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DOI：
10.1016/j.ajhg.2013.07.006
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发表时间：
2013-09-05
影响因子：
9.8
通讯作者：
Singh, Lalji
中科院分区：
文献类型：
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作者：
Moorjani, Priya;Thangaraj, Kumarasamy;Singh, Lalji
大多数印度群体都是两个遗传上不同的群体的混合后裔：祖先北印度人（与中亚人、中东人、高加索人和欧洲人有关）和祖先南印度人（ASI）与次大陆以外的群体没有密切关系。混合的日期未知，但对理解印度历史有影响。我们报告了印度次大陆 73 个群体的全基因组数据并分析了连锁不平衡 估计 ANI-ASI 混合物的年代约为 1,900 至 4,200 年前。在一组子集中，100% 的混合物与这一时期发生的情况一致。这些结果表明，印度在几千年前经历了人口结构的转变，从一个主要人口混合很常见的地区，变成了一个由于向内婚制的转变，即使是密切相关的群体之间的混合也变得很少见的地区。
Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (AND related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian history. We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy.