Population-based reference values for IGF-I and IGF-binding protein-1: relations with metabolic and anthropometric variables.
Population-based reference values for IGF-I and IGF-binding protein-1: relations with metabolic and anthropometric variables.
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基于人群的 IGF-I 和 IGF 结合蛋白-1 参考值：与代谢和人体测量变量的关系。
DOI：
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发表时间：
1997
影响因子：
5.8
通讯作者：
H. J. Arnqvist
中科院分区：
文献类型：
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作者：
Fredrik H. Nystrom;Peter Öhman;B. Ekman;Maria K Österlund;Bengt E. Karlberg;H. J. Arnqvist
已建立了基于人群的IGF-I和IGF-binding protein-1（IGFBP-1）参考值。从林雪平社区的人口登记册中随机选择了101名20-70岁的妇女和相同数量的男子。参与率为67%。在空腹状态下抽取静脉血。采用酸-乙醇提取法提取血清IGF-Ⅰ，用放免法测定血清IGF-Ⅰ，用ELISA法测定血清IGFBP-1。IGF-I水平在性别之间没有差异，男性和女性随年龄的下降相似（男性：Y = 366-3.28 x年龄（岁），r =-0.61，P < 0.0001;女性：Y = 386-3.49 x年龄，r =-0.57，P < 0.0001，P = 0.4，斜率差异）。在男性和女性中，IGF-I与血脂和血压均呈负相关，但与年龄无关。男性血清血管紧张素转换酶活性与IGF-I呈正相关，与年龄无关（r = 0.21，P = 0.01）。IGFBP-1的分布呈正偏态分布，女性高于男性（分别为5.9 +/- 4.8微克/升和4.0 +/- 3.3微克/升; Mann-Whitney，P = 0.002）。在男性和未服用雌激素的女性中，IGFBP-1与年龄呈正相关（斯皮尔曼等级相关（斯皮尔曼：男性：r = 0.32，P = 0.002;女性：r = 0.24，P = 0.03）。C肽与IGFBP-1呈负相关（斯皮尔曼：男性：r =-0.38，P = 0.002;女性：r =-0.49，P < 0.000），性激素结合球蛋白与IGFBP-1呈正相关（斯皮尔曼：男性：r = 0.50，P < 0.0001;女性：r = 0.55，P < 0.0001）。IGF-I随着年龄的增长而下降，而被认为调节IGF-I的游离生物活性部分的IGFBP-1则增加。这表明老年受试者中IGF-I活性可能甚至低于低总IGF-I所占的水平。
Population-based reference values for IGF-I and IGF-binding protein-1 (IGFBP-1) have been established. One hundred and one women and the same number of men, 20-70 years old, were randomly selected from the population registry in the community of Linköping. Participation rate was 67%. Venous blood was drawn in the fasting state. Serum IGF-I was measured by RIA after acid-ethanol extraction and IGFBP-1 was determined by ELISA. IGF-I levels did not differ between genders and the decline with age was similar in men and women (men: Y = 366-3.28 x age (years), r = -0.61, P < 0.0001; women: Y = 386-3.49 x age, r = -0.57, P < 0.0001, P = 0.4 for difference in slope). There were negative correlations between IGF-I and plasma lipids and blood pressure in both genders, but none was independent of age. Serum angiotensin-converting enzyme activity correlated positively with IGF-I in men independently from age (r = 0.21, P = 0.01). The distribution of IGFBP-1 was positively skewed and it was higher in women than in men (5.9 +/- 4.8 micrograms/l and 4.0 +/- 3.3 micrograms/l respectively; Mann-Whitney, P = 0.002). In men and in the women not taking oestrogen, IGFBP-1 correlated positively with age (Spearman rank correlation (Spearman: men: r = 0.32, P = 0.002; women: r = 0.24, P = 0.03). C-peptide correlated negatively (Spearman: men: r = -0.38, P = 0.002; women: r = -0.49, P < 0.000) and sex hormone binding globulin positively with IGFBP-1 (Spearman: men: r = 0.50, P < 0.0001; women: r = 0.55, P < 0.0001). IGF-I declined with age while IGFBP-1, which is considered to modulate the free bioactive fraction of IGF-I, increased. This suggests that IGF-I activity might be even lower in elderly subjects than is accounted for by the low total IGF-I.
影响因子：
5.8
作者：
HO, KY;EVANS, WS;THORNER, MO
通讯作者：
THORNER, MO