Enzymatic Kinetic Resolution by Addition of Oxygen
Enzymatic Kinetic Resolution by Addition of Oxygen
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通过添加氧气进行酶促动力学拆分
DOI：
10.1002/ange.202011468
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发表时间：
2020
影响因子：
--
通讯作者：
Harwood L
中科院分区：
文献类型：
--
作者：
Harwood L
利用生物催化的动力学拆分已被证明是传统不对称催化合成对映体富集物的一种很好的补充技术。使用氧化酶的拆分产生有价值的含氧结构，用于合成路线的开发。这篇简短的综述重点介绍了催化氧原子插入底物并通过这样做可以实现氧化动力学拆分的酶。包括Baeyer-Villiger重排、环氧化和羟化反应，并讨论了酶开发的生物学进展，以及这些关键的富含对映体的中间体在天然产物合成中的应用。
Kinetic resolution using biocatalysis has proven to be an excellent complementary technique to traditional asymmetric catalysis for the production of enantioenriched compounds. Resolution using oxidative enzymes produces valuable oxygenated structures for use in synthetic route development. This Minireview focuses on enzymes which catalyse the insertion of an oxygen atom into the substrate and, in so doing, can achieve oxidative kinetic resolution. The Baeyer–Villiger rearrangement, epoxidation, and hydroxylation are included, and biological advancements in enzyme development, and applications of these key enantioenriched intermediates in natural product synthesis are discussed.