Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study
Oval cells in hepatitis B virus-positive and hepatitis C virus-positive liver cirrhosis: histological and ultrastructural study
复制标题
DOI：
10.1111/j.1365-2559.2006.02372.x
复制
发表时间：
2006-04-01
期刊：
影响因子：
6.4
通讯作者：
Xiao, JC
中科院分区：
文献类型：
--
作者：
Sun, C;Jin, XL;Xiao, JC
目的：目前尚不清楚卵圆细胞是否在不同的人类肝脏疾病中表现出不同的形态、免疫表型或数量。本研究的目的是探讨这些差异在肝炎B病毒（HBV）阳性和丙型肝炎病毒（HCV）阳性的人肝硬化（HLC）。方法和结果：38例HBV+ HLC和32例HCV+ HLC的光镜和免疫组化肝细胞，CK19，干细胞因子（SCF）和CD34。5例还进行了透射电镜检查。两组增殖期胆管内可见形态相似的卵圆细胞。这些细胞共表达CK19和Hepatocyte，但不表达SCF和CD 34。这些细胞中的一些表现出分化的趋势。两组卵圆细胞数量无差异。卵圆细胞的数量随着炎症的进展而显著增加。结论：HBV+和HCV+ HLC中均存在双能卵圆细胞。两组间卵圆细胞无差异提示它们可能在不同肝脏疾病的组织发生中起相似的生物学作用。
Aims: It is still not clear whether oval cells demonstrate diverse morphology, immunophenotype or quantity in different human liver diseases. The aim of this study was to investigate these differences in hepatitis B virus (HBV)-positive and hepatitis C virus (HCV)-positive human liver cirrhosis (HLC).Methods and results: Thirty-eight cases of HBV+ HLC and 32 cases of HCV+ HLC were investigated by light microscopy and immunohistochemistry for Hepatocyte, CK19, stem cell factor (SCF) and CD34. Five cases were also examined by transmission electron microscopy. Oval cells of similar morphology could be found in proliferating bile ductules in both groups. These cells coexpressed CK19 and Hepatocyte, but did not express SCF or CD34. Some of these cells exhibited a trend towards differentiation. There was no difference in the amount of oval cells between the two groups. The oval cell number was found to increase significantly with the progression of inflammation. A similar stem-like cell was not seen in the normal liver.Conclusions: There are bipotential oval cells in both HBV+ and HCV+ HLC. The lack of difference in oval cells between the two groups suggests that they might play a similar biological role in the histogenesis of different liver diseases.