MicroRNAs in human glioblastoma: from bench to beside.
MicroRNAs in human glioblastoma: from bench to beside.
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DOI：
10.2741/4300
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Hongxiang Wang;Tao Xu;Ying Jiang;Yong Yan;R. Qin;Juxiang Chen
中科院分区：
文献类型：
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作者：
Hongxiang Wang;Tao Xu;Ying Jiang;Yong Yan;R. Qin;Juxiang Chen
胶质母细胞瘤（GBM）是最常见和恶性的成人原发性脑肿瘤，也是所有癌症中最致命的类型之一。目前，尽管进行了介入治疗（例如手术、放疗和化疗的多模式治疗），GBM患者的总体预后仍然很差。因此，有必要了解GBM的分子发病机制，为现代治疗提供新的见解。microRNA（miRNA）作为一种新的分子，参与了包括GBM在内的多种肿瘤的发病机制。到目前为止，miRNA已被证明在调节蛋白质编码基因的表达中起作用。这使得miRNA在调节各种细胞事件中具有直接功能，包括细胞增殖、凋亡和分化。近年来，肿瘤相关miRNAs及其靶基因的研究取得了很大进展。本文就miRNAs及其在GBM调控中的作用作一综述。此外，我们还总结了一些发现作为GBM生物标志物的miRNAs及其在治疗中的作用。
Glioblastoma (GBM) is the most common and malignant adult primary brain tumor and one of the most lethal types of all cancers. Currently, despite interventional therapy (e.g. multimodal treatments with surgery, radiotherapy and chemotherapy), the overall prognosis for GBM patients remains poor. Thus, it is necessary to understand the molecular pathogenesis of GBM, which provides new insight into modern therapy. As a novel molecule, microRNA (miRNA) contributes to the pathogenesis of various types of tumor, including GBM. So far, miRNA has been shown to function in regulating protein-coding gene expression. This allows miRNAs to have direct function in regulation of various cellular events, including cell proliferation, apoptosis, and differentiation. Great progress has been made in identifying novel tumor-related miRNAs and their potential target genes. In this review, we focus on the most current research in miRNAs and their role in GBM regulation. In addition, we summarize some miRNAs found as biomarkers in GBM and their role in treatment.