Development and stability of postional information in Xenopus retinal ganglion cells.
Development and stability of postional information in Xenopus retinal ganglion cells.
复制标题
非洲爪蟾视网膜神经节细胞位置信息的发展和稳定性。
DOI：
10.1073/pnas.69.4.780
复制
发表时间：
1972
影响因子：
11.1
通讯作者：
M. Jacobson
中科院分区：
文献类型：
--
作者：
R. Hunt;M. Jacobson
非洲爪蟾视网膜神经节细胞的神经元特异性维持视神经纤维在顶盖的有序连接。这种特异性来源于胚胎期28-31的视网膜发育所获得的位置信息。在这里，我们报告说，神经节细胞的胚胎阶段28只眼睛可以获得的位置信息，参考身体的主轴不仅在眼眶，但也在其他位置上的身体一侧。当返回到眼眶时，这只眼睛将形成适当的视网膜顶盖连接。相反，如果通过将眼睛移植到侧腹30天然后将其返回到眼眶来延迟视网膜顶盖连接的形成，则已经在眼眶中获得位置信息的阶段31眼睛的视网膜神经节细胞将保留其原始神经元位置特异性。我们的结论是，视网膜神经节细胞的神经元特异性（a）不来自“诱导剂”独特的眼周组织;和（B）持续一段时间的独立的视网膜顶盖连接的建立。
Neuronal specificity in retinal ganglion cells of Xenopus subserves the orderly connections of the optic nerve fibers in the tectum. This specificity derives from positional information acquired by the developing retina at embryonic stages 28-31. Here we report that ganglion cells of embryonic stage 28 eyes can acquire positional information with reference to the major axes of the body not only in the ocular orbit but also at other positions on the side of the body. When returned to the orbit this eye will form appropriate retinotectal connections. Conversely, retinal ganglion cells of stage 31 eyes, which have acquired positional information in the orbit, will retain their original neuronal positional specificities if the formation of retinotectal connections is delayed by grafting the eye to the flank for 30 days before returning it to the orbit. We conclude that neuronal specificity of retinal ganglion cells (a) does not derive from "inducers" unique to the periocular tissues; and (b) persists for some time independently of the establishment of retinotectal connections.