From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis.
From Photoinduced to Dark Cytotoxicity through an Octahedral Cluster Hydrolysis.
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DOI：
10.1002/chem.201804663
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发表时间：
2018-11
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影响因子：
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通讯作者：
Ekaterina V. Svezhentseva;Yuri A. Vorotnikov;A. Solovieva;T. Pozmogova;I. Eltsov;A. Ivanov;D. V. Evtushok-D.-V.
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文献类型：
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作者：
Ekaterina V. Svezhentseva;Yuri A. Vorotnikov;A. Solovieva;T. Pozmogova;I. Eltsov;A. Ivanov;D. V. Evtushok-D.-V.
八面体钼、钨簇合物在光动力学治疗和生物成像等方面具有潜在的生物学应用价值。然而，这些化合物的溶解性和水解稳定性差，阻碍了它们的应用。合成了第一个水溶性光致发光八面体钨簇合物[{W 6 I8 }（DMSO）6 ]（NO3）4，并证明其水解稳定性比其钼类似物高至少一个数量级。该化合物对喉癌细胞的生物学研究表明，它具有明显的光诱导毒性，而暗毒性随水解度的增加而增加。暗毒性的增加与原位生成的纳米颗粒堵塞粗面内质网池有关。
Octahedral molybdenum and tungsten clusters have potential biological applications in photodynamic therapy and bioimaging. However, poor solubility and hydrolysis stability of these compounds hinder their application. The first water-soluble photoluminescent octahedral tungsten cluster [{W6 I8 }(DMSO)6 ](NO3 )4 was synthesised and demonstrated to be at least one order of magnitude more stable towards hydrolysis than its molybdenum analogue. Biological studies of the compound on larynx carcinoma cells suggest that it has a significant photoinduced toxicity, while the dark toxicity increases with the increase of the degree of hydrolysis. The increase of the dark toxicity is associated with the in situ generation of nanoparticles that clog up the cisternae of rough endoplasmic reticulum.