Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion
Coexistence of dilute and densely packed domains of ligand-receptor bonds in membrane adhesion
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DOI：
10.1209/0295-5075/99/38003
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发表时间：
2012-08-01
期刊：
影响因子：
1.8
通讯作者：
Smith, Ana-Suncana
中科院分区：
文献类型：
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作者：
Schmidt, Daniel;Bihr, Timo;Smith, Ana-Suncana
我们分析了介导生物模型膜黏附的配体-受体键的微域的稳定性。在评估了膜波动对单键结合亲和力的影响后，我们用理论方法表征了结构域内键的组织。在很大的参数范围内，我们发现通常建议的致密堆积被自由能垒与键稀疏分布的区域分开。如果键是流动的，应该会出现两种机制共存的情况，这与最近的实验观察一致。版权所有(C)Epla，2012
We analyze the stability of micro-domains of ligand-receptor bonds that mediate the adhesion of biological model membranes. After evaluating the effects of membrane fluctuations on the binding affinity of a single bond, we characterize the organization of bonds within the domains by theoretical means. In a large range of parameters, we find the commonly suggested dense packing to be separated by a free energy barrier from a regime in which bonds are sparsely distributed. If bonds are mobile, a coexistence of the two regimes should emerge, which agrees with recent experimental observations. Copyright (C) EPLA, 2012