The African diaspora: history, adaptation and health
The African diaspora: history, adaptation and health
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DOI：
10.1016/j.gde.2016.08.005
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发表时间：
2016-12-01
影响因子：
4
通讯作者：
Shriner, Daniel
中科院分区：
文献类型：
--
作者：
Rotimi, Charles N.;Tekola-Ayele, Fasil;Shriner, Daniel
跨大西洋奴隶贸易将数百万非洲人带到了新大陆。基因组学的进步为非洲人和散居人口的历史和健康提供了新的见解。这里回顾的最近的例子包括撒哈拉以南非洲大量狩猎采集者和“欧亚”混合物的解开，扩大了我们对非洲祖先遗传学的理解;混合祖先的全球普遍性;拉丁美洲人的非洲祖先可能来自奴隶贸易的揭示;以及对APOL 1和LPL的祖先背景的理解，发现它们分别影响肾脏疾病和脂质水平，对疾病病因和健康差异提供了具体的见解。
The trans-Atlantic slave trade brought millions of Africans to the New World. Advances in genomics are providing novel insights into the history and health of Africans and the diasporan populations. Recent examples reviewed here include the unraveling of substantial hunter-gatherer and 'Eurasian' admixtures across sub-Saharan Africa, expanding our understanding of ancestral African genetics; the global ubiquity of mixed ancestry; the revealing of African ancestry in Latin Americans that likely derived from the slave trade; and understanding of the ancestral backgrounds of APOL1 and LPL found to influence kidney disease and lipid levels, respectively, providing specific insights into disease etiology and health disparities.