Ethnic Differences in and Childhood Influences on Early Adult Pulse Wave Velocity: The Determinants of Adolescent, Now Young Adult, Social Wellbeing, and Health Longitudinal Study.
Ethnic Differences in and Childhood Influences on Early Adult Pulse Wave Velocity: The Determinants of Adolescent, Now Young Adult, Social Wellbeing, and Health Longitudinal Study.
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DOI：
10.1161/hypertensionaha.115.07079
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发表时间：
2016-06
期刊：
影响因子：
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通讯作者：
Harding S
中科院分区：
文献类型：
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作者：
Cruickshank JK;Silva MJ;Molaodi OR;Enayat ZE;Cassidy A;Karamanos A;Read UM;Faconti L;Dall P;Stansfield B;Harding S
补充数字内容可在文本中找到。主动脉僵硬的早期决定因素如脉搏波速度了解甚少。我们在一项多种族队列研究中测试了儿童时期两次测量的因素，特别是体重、血压，并客观评估了体育活动对年轻人主动脉僵硬的影响。6643名年龄在11至13岁的伦敦儿童，来自51所学校的6个不同心血管风险种族的样本中，4785名（72%）在14至16岁时再次出现。2013年，666人（97%的受邀者）参加了一项年轻人（21-23岁）的试点随访。通过社会心理和人体测量测量，通过上臂校准动脉造影装置记录主动脉僵硬度和血压。在一个子样本（n=334）中，通过ActivPal每50天测量一次身体活动。加勒比黑人和英国白人年轻男性未经调整的脉搏波速度相似（平均±SD 7.9±0.3 vs 7.6±0.4 m/s），在收缩压（120 mm Hg）和体重（24.6 kg/m2）相似的其他组中更低。在完全调整的回归模型中，独立于压力的影响，加勒比黑人（较高的体重/腰围）、非洲黑人和印度年轻女性的僵硬度（0.5-0.8；95%可信区间为0.1-1.1 m/s）低于英国白人女性（6.9±0.2 m/s）。年龄、压力、腰/身高的强大影响、久坐时间和种族歧视效应（+0.3 m/s）分别增加了数值。以bbb100步/分钟步行时间与僵硬程度降低相关（P<0.01）。检测儿童腰/髋部的影响。到成年早期，腰高比增加，体力活动减少，血压和社会心理变量（例如，感知到的种族主义）独立地增加动脉僵硬，影响可能随着年龄的增长而增加。
Supplemental Digital Content is available in the text. Early determinants of aortic stiffness as pulse wave velocity are poorly understood. We tested how factors measured twice previously in childhood in a multiethnic cohort study, particularly body mass, blood pressure, and objectively assessed physical activity affected aortic stiffness in young adults. Of 6643 London children, aged 11 to 13 years, from 51 schools in samples stratified by 6 ethnic groups with different cardiovascular risk, 4785 (72%) were seen again at aged 14 to 16 years. In 2013, 666 (97% of invited) took part in a young adult (21–23 years) pilot follow-up. With psychosocial and anthropometric measures, aortic stiffness and blood pressure were recorded via an upper arm calibrated Arteriograph device. In a subsample (n=334), physical activity was measured >5 days via the ActivPal. Unadjusted pulse wave velocities in black Caribbean and white UK young men were similar (mean±SD 7.9±0.3 versus 7.6±0.4 m/s) and lower in other groups at similar systolic pressures (120 mm Hg) and body mass (24.6 kg/m2). In fully adjusted regression models, independent of pressure effects, black Caribbean (higher body mass/waists), black African, and Indian young women had lower stiffness (by 0.5–0.8; 95% confidence interval, 0.1–1.1 m/s) than did white British women (6.9±0.2 m/s). Values were separately increased by age, pressure, powerful impacts from waist/height, time spent sedentary, and a reported racism effect (+0.3 m/s). Time walking at >100 steps/min was associated with reduced stiffness (P<0.01). Effects of childhood waist/hip were detected. By young adulthood, increased waist/height ratios, lower physical activity, blood pressure, and psychosocial variables (eg, perceived racism) independently increase arterial stiffness, effects likely to increase with age.