Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy
Human Umbilical Cord Mesenchymal Stem Cells: A New Era for Stem Cell Therapy
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DOI：
10.3727/096368915x686841
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发表时间：
2015-01-01
影响因子：
3.3
通讯作者：
Lin, Shinn-Zong
中科院分区：
文献类型：
--
作者：
Ding, Dah-Ching;Chang, Yu-Hsun;Lin, Shinn-Zong
人脐带是间充质干细胞（HUCMSCs）的一个有前途的来源。与骨髓干细胞不同，HUCMSC具有无痛的收集过程和更快的自我更新特性。不同的衍生方案可以提供不同数量和群体的干细胞。干细胞群体也被报道存在于脐带的其他隔室中，例如脐带衬里、血管周围组织和沃顿氏胶质。与胚胎干细胞相比，HUCMSC是无争议的来源。它们可以分化成三个胚层，促进组织修复，调节免疫反应和抗癌特性。因此，它们是用于治疗恶性和非恶性实体和软肿瘤的有吸引力的自体或同种异体药剂。HUCMC也可以是胚胎干细胞或其他多能干细胞的饲养层。考虑到其治疗价值，应立即建立储存库系统和方案。
The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs). Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster self-renewal properties. Different derivation protocols may provide different amounts and populations of stem cells. Stem cell populations have also been reported in other compartments of the umbilical cord, such as the cord lining, perivascular tissue, and Wharton's jelly. HUCMSCs are noncontroversial sources compared to embryonic stem cells. They can differentiate into the three germ layers that promote tissue repair and modulate immune responses and anticancer properties. Thus, they are attractive autologous or allogenic agents for the treatment of malignant and nonmalignant solid and soft cancers. HUCMCs also can be the feeder layer for embryonic stem cells or other pluripotent stem cells. Regarding their therapeutic value, storage banking system and protocols should be established immediately.