Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance.
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DOI：
10.1084/jem.20110767
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发表时间：
2011-09-26
期刊：
影响因子：
--
通讯作者：
Waldmann H
中科院分区：
文献类型：
--
作者：
Kendal AR;Chen Y;Regateiro FS;Ma J;Adams E;Cobbold SP;Hori S;Waldmann H
一种新的小鼠遗传模型证明了Foxp3+ T regg细胞对感染性耐受的必要性。最近发现了调节性T细胞（T reg细胞），其中CD4+Foxp3+细胞被证明对自我耐受至关重要，这是免疫学的一个范式转变。使用转基因B6。利用抗hcd2抗体分离和消融Foxp3+ T细胞，我们首次证明了CD4+Foxp3+细胞对非消融性抗T细胞抗体诱导的感染耐受至关重要。在耐受动物中，Foxp3+ T regg细胞不断被要求抑制仍然能够引起组织损伤的效应T细胞。耐受组织含有能够排斥它的T细胞，但通过治疗诱导Foxp3+ T regg细胞阻止了这种排斥。最后，Foxp3+细胞已被证实是感染耐受在体内运作的关键缺失环节。外周诱导的Foxp3+细胞通过将初始T细胞转化为下一代Foxp3+细胞来维持耐受性。在体内激活Foxp3+调节性T细胞为避免和纠正组织免疫病理提供了一种可行的途径。
A new genetic mouse model demonstrates the necessity of Foxp3+ T reg cells for infectious tolerance. A paradigm shift in immunology has been the recent discovery of regulatory T cells (T reg cells), of which CD4+Foxp3+ cells are proven as essential to self-tolerance. Using transgenic B6.Foxp3hCD2 mice to isolate and ablate Foxp3+ T reg cells with an anti-hCD2 antibody, we show for the first time that CD4+Foxp3+ cells are crucial for infectious tolerance induced by nonablative anti–T cell antibodies. In tolerant animals, Foxp3+ T reg cells are constantly required to suppress effector T cells still capable of causing tissue damage. Tolerated tissue contains T cells that are capable of rejecting it, but are prevented from doing so by therapeutically induced Foxp3+ T reg cells. Finally, Foxp3+ cells have been confirmed as the critical missing link through which infectious tolerance operates in vivo. Peripherally induced Foxp3+ cells sustain tolerance by converting naive T cells into the next generation of Foxp3+ cells. Empowering Foxp3+ regulatory T cells in vivo offers a tractable route to avoid and correct tissue immunopathology.
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介导同种异体移植耐受性的FOXP3+ T调节细胞的募集取决于CCR4趋化因子受体。
影响因子：
15.3
作者：
Lee, I;Wang, LQ;Wells, AD;Dorf, ME;Ozkaynak, E;Hancock, WW
通讯作者：
Hancock, WW
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
6.2
作者：
Feng, Gang;Wood, Kathryn J.;Bushell, Andrew
通讯作者：
Bushell, Andrew
DOI：
10.1084/jem.20020394
发表时间：
2002-07-15
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jonuleit H;Schmitt E;Kakirman H;Stassen M;Knop J;Enk AH
通讯作者：
Enk AH