Towards an MMP-2-activated molecular agent for cancer imaging.
Towards an MMP-2-activated molecular agent for cancer imaging.
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用于癌症成像的 MMP-2 激活分子制剂。
DOI：
10.1039/c7dt03108d
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Cowell S
中科院分区：
文献类型：
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作者：
Cowell S
基质金属蛋白酶（MMPs）已被确定为癌症的生物标志物，提供预后潜力;然而，目前缺乏非侵入性检测方案。在此，我们描述了一种含DOTA的肽序列的合成，该肽序列可以容易地用68镓进行放射性标记，或者可以与钆结合用于可能的MRI应用，对MMP-2的选择性明显高于MMP家族的其他成员，从而使MMP-2选择性切割标记的肽。
Matrix metalloproteinases (MMPs) have been identified as biomarkers for cancer, offering prognostic potential; however, non-invasive detection protocols are currently lacking. Herein, we describe the synthesis of a DOTA-containing peptide sequence that can be radiolabelled easily with 68Gallium or can be incorporated with gadolinium for possible MRI applications with clear selectivity for MMP-2 over other members of the MMP family, giving MMP-2 selective cleavage of the labelled peptides.