CIRCULATING miR-155 EXPRESSION IN PLASMA: A POTENTIAL BIOMARKER FOR EARLY DIAGNOSIS OF ESOPHAGEAL CANCER IN HUMANS
CIRCULATING miR-155 EXPRESSION IN PLASMA: A POTENTIAL BIOMARKER FOR EARLY DIAGNOSIS OF ESOPHAGEAL CANCER IN HUMANS
复制标题
血浆中循环 miR-155 表达：人类食管癌早期诊断的潜在生物标志物
DOI：
10.1080/15287394.2012.699856
复制
发表时间：
2012-01-01
影响因子：
2.6
通讯作者：
Yin, Lihong
中科院分区：
文献类型：
--
作者：
Liu, Ran;Liao, Juan;Yin, Lihong
MicroRNAs(MiRNAs)被认为在肿瘤发生中发挥重要作用。最近，在疾病患者的血浆或血清中检测到了胞外miRNAs。然而，循环中的miRNAs在血浆/血清中的作用仍有待阐明。在这项研究中，食道组织中miR-155、miR-183和miR-20a的相对表达被发现与食道癌风险的增加显著相关。肿瘤患者外周血中miR-155和miR-183的相对表达明显降低。根据吸烟状况和饮酒情况调整后，循环中的miR-155患食道癌的风险显著增加。循环miR-155对食道癌有显著的诊断价值，受试者工作特征曲线面积为66%。然而，Pearson分析显示，血浆和食道组织中miRNAs的相对表达没有统计学相关性，这表明循环中miRNAs的来源不同于肿瘤细胞miRNAs。综上所述，血浆中循环miR-155可能是一种可靠的、新颖的、无创的食管癌早期诊断和检测的生物标志物。
MicroRNAs (miRNAs) are postulated to play important roles in oncogenesis. Recently, extracellular miRNAs were detected in plasma or serum of diseased subjects. However, the role of circulating miRNAs in plasma/serum remains to be elucidated. In this study, the relative expressions of miR-155, miR-183, and miR-20a in esophageal tissue were found to be significantly associated with increased risk for esophageal cancer. The relative expressions of circulating miR-155 and miR-183 were significantly reduced in cancer patients. Circulating miR-155 showed significantly higher risk for esophageal cancer when adjusted by smoking status and alcohol use. Circulating miR-155 was found to have significant diagnostic value for esophageal cancer as evidenced by a receiver operating characteristic curve area of 66%. However, Pearson analysis showed no statistical correlation in the relative miRNAs expression between plasma and esophageal tissues, which suggested different origins of circulating miRNAs distinct from tumor cell miRNAs. In conclusion, results suggest that circulating miR-155 in plasma may serve as a reliable, novel, noninvasive biomarker for early diagnosis and detection of esophageal cancer.