Mechanical interactions between adjacent airways in the lung
Mechanical interactions between adjacent airways in the lung
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DOI：
10.1152/japplphysiol.01180.2013
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发表时间：
2014-03-01
影响因子：
3.3
通讯作者：
Bates, Jason H. T.
中科院分区：
文献类型：
--
作者：
Ma, Baoshun;Bates, Jason H. T.
气道和肺实质之间的机械相互依赖力是气道反应性的强大调节剂。然而，很少有人知道，在何种程度上相邻的气道影响对方的能力，缩小由于扭曲力内产生的干预实质。我们开发了一个二维计算模型的两个气道嵌入实质。薄壁组织本身以三种方式建模：1）作为六边形排列的弹簧网络，2）作为三角形排列的弹簧网络，以及3）作为弹性连续体。在所有情况下，我们确定了当另一个气道放松时与当它缩小到与第一个气道相同的程度时，一个气道的狭窄是如何受到影响的。对于连续体和三角形网络模型，气道之间的相互作用可以忽略不计，除非气道位于彼此的约两个松弛直径内，但即使在这个距离处，相互作用也很小。相比之下，六边形弹簧网络模型预测，在气道收缩力的中间值下，对于任何程度的气道分离，由实质介导的气道-气道相互作用都是实质性的。迄今为止的证据表明，实质可能更好地代表了连续模型，这表明，实质不介导狭窄气道之间的显着相互作用。
The forces of mechanical interdependence between the airways and the parenchyma in the lung are powerful modulators of airways responsiveness. Little is known, however, about the extent to which adjacent airways affect each other's ability to narrow due to distortional forces generated within the intervening parenchyma. We developed a two-dimensional computational model of two airways embedded in parenchyma. The parenchyma itself was modeled in three ways: 1) as a network of hexagonally arranged springs, 2) as a network of triangularly arranged springs, and 3) as an elastic continuum. In all cases, we determined how the narrowing of one airway was affected when the other airway was relaxed vs. when it narrowed to the same extent as the first airway. For the continuum and triangular network models, interactions between airways were negligible unless the airways lay within about two relaxed diameters of each other, but even at this distance the interactions were small. By contrast, the hexagonal spring network model predicted that airway-airway interactions mediated by the parenchyma can be substantial for any degree of airway separation at intermediate values of airway contraction forces. Evidence to date suggests that the parenchyma may be better represented by the continuum model, which suggests that the parenchyma does not mediate significant interactions between narrowing airways.