Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19.
Cell Death in Coronavirus Infections: Uncovering Its Role during COVID-19.
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DOI：
10.3390/cells10071585
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发表时间：
2021-06-23
期刊：
影响因子：
6
通讯作者：
Gibellini L
中科院分区：
文献类型：
--
作者：
Paolini A;Borella R;De Biasi S;Neroni A;Mattioli M;Lo Tartaro D;Simonini C;Franceschini L;Cicco G;Piparo AM;Cossarizza A;Gibellini L
细胞死亡机制对于维持健康细胞功能的适当环境至关重要。然而，在病毒感染期间，这些过程的失调可能存在，并可能参与疾病的发病机制。本文综述了严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的一些特征，以及当前冠状病毒病（COVID-19）的一些免疫致病机制。淋巴细胞减少症和单核细胞减少症是COVID-19免疫发病的重要因素。这些现象背后的精细机制尚不清楚，人们提出了几种假设，其中一些假设认为，就特定类型免疫细胞的减少而言，细胞死亡起着重要作用。因此，我们讨论了凋亡、坏死下垂和焦下垂三种主要途径，并认为它们可能同时发生在COVID-19患者中。我们描述了SARS-CoV-2在诱导细胞死亡中既可以起到直接作用，也可以起到间接作用。事实上，一方面，细胞死亡可能是由病毒进入细胞引起的，另一方面，细胞因子和趋化因子浓度过高，这一过程被称为与covid -19相关的细胞因子风暴，对循环免疫细胞产生有害影响。然而，对这些机制的全面了解仍然很少，需要进一步的研究来描述新的治疗策略。
Cell death mechanisms are crucial to maintain an appropriate environment for the functionality of healthy cells. However, during viral infections, dysregulation of these processes can be present and can participate in the pathogenetic mechanisms of the disease. In this review, we describe some features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and some immunopathogenic mechanisms characterizing the present coronavirus disease (COVID-19). Lymphopenia and monocytopenia are important contributors to COVID-19 immunopathogenesis. The fine mechanisms underlying these phenomena are still unknown, and several hypotheses have been raised, some of which assign a role to cell death as far as the reduction of specific types of immune cells is concerned. Thus, we discuss three major pathways such as apoptosis, necroptosis, and pyroptosis, and suggest that all of them likely occur simultaneously in COVID-19 patients. We describe that SARS-CoV-2 can have both a direct and an indirect role in inducing cell death. Indeed, on the one hand, cell death can be caused by the virus entry into cells, on the other, the excessive concentration of cytokines and chemokines, a process that is known as a COVID-19-related cytokine storm, exerts deleterious effects on circulating immune cells. However, the overall knowledge of these mechanisms is still scarce and further studies are needed to delineate new therapeutic strategies.
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影响因子：
3.2
作者：
Brazeau E;Mahalingam R;Gilden D;Wellish M;Kaufer BB;Osterrieder N;Pugazhenthi S
通讯作者：
Pugazhenthi S
影响因子：
9.3
作者：
Cao L;Mu W
通讯作者：
Mu W
影响因子：
11.4
作者：
Chang, DW;Xing, Z;Yang, XL
通讯作者：
Yang, XL
影响因子：
46.9
作者：
Chua, Robert Lorenz;Lukassen, Soeren;Eils, Roland
通讯作者：
Eils, Roland
DOI：
10.1126/science.abc6261
发表时间：
2020-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arunachalam PS;Wimmers F;Mok CKP;Perera RAPM;Scott M;Hagan T;Sigal N;Feng Y;Bristow L;Tak-Yin Tsang O;Wagh D;Coller J;Pellegrini KL;Kazmin D;Alaaeddine G;Leung WS;Chan JMC;Chik TSH;Choi CYC;Huerta C;Paine McCullough M;Lv H;Anderson E;Edupuganti S;Upadhyay AA;Bosinger SE;Maecker HT;Khatri P;Rouphael N;Peiris M;Pulendran B
通讯作者：
Pulendran B