The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells
The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells
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DOI：
10.1016/s0304-3835(97)04716-2
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发表时间：
1997-05-01
期刊：
影响因子：
9.7
通讯作者：
McLaughlin, JL
中科院分区：
文献类型：
--
作者：
Oberlies, NH;Croy, VL;McLaughlin, JL
研究番荔枝内酯布拉他星对多药耐药(MDR)人乳腺癌细胞(MCF-7/ADR)和亲代非耐药野生型(MCF-7/wt)细胞的细胞毒作用。布拉他星对MCF-7/ADR细胞有较强的细胞毒作用，而对MCF-7/wt细胞的细胞毒作用较强。三磷酸腺苷耗竭是番荔枝内酯的作用方式，对于具有三磷酸腺苷依赖机制的多药耐药肿瘤的化疗具有独特的优势。(C)1997年爱思唯尔爱尔兰科学有限公司。
Cytotoxic effects of the Annonaceous acetogenin, bullatacin, were studied in multidrug-resistant (MDR) human mammary adenocarcinoma (MCF-7/Adr) cells vs. the parental non-resistant wild type (MCF-7/wt) cells. Bullatacin was effectively cytotoxic to the MCF-7/Adr cells while it was more cytostatic to the MCF-7/wt cells. ATP depletion is the mode of action of the Annonaceous acetogenins, and these agents offer a special advantage in the chemotherapeutic treatment of MDR tumors that have ATP-dependent mechanisms. (C) 1997 Elsevier Science Ireland Ltd.