Multi-component heteroarene couplings via polarity-reversed radical cascades
Multi-component heteroarene couplings via polarity-reversed radical cascades
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DOI：
10.1039/c9cc03498f
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发表时间：
2019-08-04
影响因子：
4.9
通讯作者：
Nagib, David A.
中科院分区：
文献类型：
--
作者：
Lear, Jeremy M.;Buquoi, J. Quentin;Nagib, David A.
多组分自由基加成策略使得烯烃与杂芳烃和各种自由基前体（包括N-3、P（O）R-2和CF 3）的双官能化成为可能。这种用于将不同种类的亲电基团和杂芳烃偶联到乙烯基醚的统一方法允许直接的邻位C-C以及C-N、C-P和C-R-f键的形成。
A multi-component radical addition strategy enables difunctionalization of alkenes with heteroarenes and a variety of radical precursors, including N-3, P(O)R-2, and CF3. This unified approach for coupling diverse classes of electrophilic radicals and heteroarenes to vinyl ethers allows for direct, vicinal C-C as well as C-N, C-P, and C-R-f bond formation.