Concise Review: Aggressive Colorectal Cancer: Role of Epithelial Cell Adhesion Molecule in Cancer Stem Cells and Epithelial-to-Mesenchymal Transition.
Concise Review: Aggressive Colorectal Cancer: Role of Epithelial Cell Adhesion Molecule in Cancer Stem Cells and Epithelial-to-Mesenchymal Transition.
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DOI：
10.1002/sctm.17-0289
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发表时间：
2018-06
影响因子：
6
通讯作者：
Seeber A
中科院分区：
文献类型：
--
作者：
Boesch M;Spizzo G;Seeber A
结直肠癌是世界范围内最常见的恶性肿瘤之一。尽管有各种尝试通过加强治疗来改善结果，但缺乏显著的改善，特别是在辅助治疗方面。已经提出，癌症干细胞（CSC）和上皮-间充质转化（EMT）至少部分负责CRC中的治疗抗性。上皮细胞粘附分子（EpCAM）是最早被描述的CSC抗原之一。此外，EpCAM特异性抗体（依地莫单抗）的优点是在20世纪90年代开启了肿瘤学单克隆抗体治疗的时代。然而，尽管最初有很大的热情，单克隆抗体治疗尚未证明在CRC患者的辅助治疗中是成功的。与此同时，对EpCAM在CRC中的功能的新见解已经出现，并且已经开发了针对各种表位的新药。在这篇综述文章中，我们提供了EpCAM在CSC和EMT中作用的最新信息，并强调了新治疗策略和精细临床试验设计的潜在预测选择标准。干细胞转化医学2018;7：495-501
Colorectal cancer (CRC) is one of the most common malignancies worldwide. In spite of various attempts to ameliorate outcome by escalating treatment, significant improvement is lacking particularly in the adjuvant setting. It has been proposed that cancer stem cells (CSCs) and the epithelial‐to‐mesenchymal transition (EMT) are at least partially responsible for therapy resistance in CRC. The epithelial cell adhesion molecule (EpCAM) was one of the first CSC antigens to be described. Furthermore, an EpCAM‐specific antibody (edrecolomab) has the merit of having launched the era of monoclonal antibody treatment in oncology in the 1990s. However, despite great initial enthusiasm, monoclonal antibody treatment has not proven successful in the adjuvant treatment of CRC patients. In the meantime, new insights into the function of EpCAM in CRC have emerged and new drugs targeting various epitopes have been developed. In this review article, we provide an update on the role of EpCAM in CSCs and EMT, and emphasize the potential predictive selection criteria for novel treatment strategies and refined clinical trial design. stem cells translational medicine 2018;7:495–501
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DOI：
10.1083/jcb.139.5.1337
发表时间：
1997-12-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Litvinov SV;Balzar M;Winter MJ;Bakker HA;Briaire-de Bruijn IH;Prins F;Fleuren GJ;Warnaar SO
通讯作者：
Warnaar SO
影响因子：
16.6
作者：
Li J;Yu B;Deng P;Cheng Y;Yu Y;Kevork K;Ramadoss S;Ding X;Li X;Wang CY
通讯作者：
Wang CY
影响因子：
3.7
作者：
Balzar, M;Prins, FA;Litvinov, SV
通讯作者：
Litvinov, SV
影响因子：
--
作者：
Boesch M;Zeimet AG;Reimer D;Schmidt S;Gastl G;Parson W;Spoeck F;Hatina J;Wolf D;Sopper S
通讯作者：
Sopper S
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.