tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression.
tRNA-Derived Fragments (tRFs): Emerging New Roles for an Ancient RNA in the Regulation of Gene Expression.
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DOI：
10.3390/life5041638
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发表时间：
2015-11-27
期刊：
影响因子：
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通讯作者：
Hutvagner G
中科院分区：
文献类型：
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作者：
Keam SP;Hutvagner G
本文综述了近年来从tRNA衍生的短非编码RNA（称为tRNA衍生片段（tRFs））的发现和研究现状。它将描述这些RNA的已知亚型的特征;包括序列特征、蛋白质相互作用物、表达特征、生物起源以及与典型miRNA途径的相似性。也将讨论它们在调节基因表达中的作用，包括介导翻译抑制。我们还强调了它们作为生物标志物的潜在用途，在基因调控中的功能以及与疾病的联系。最后，这篇评论将推测这类新的非编码RNA之间的原核生物和真核生物的保护的起源和理由。
This review will summarise the recent discoveries and current state of research on short noncoding RNAs derived from tRNAs—known as tRNA-derived fragments (tRFs). It will describe the features of the known subtypes of these RNAs; including sequence characteristics, protein interactors, expression characteristics, biogenesis, and similarity to canonical miRNA pathways. Also their role in regulating gene expression; including mediating translational suppression, will be discussed. We also highlight their potential use as biomarkers, functions in gene regulation and links to disease. Finally, this review will speculate as to the origin and rationale for the conservation of this novel class of noncoding RNAs amongst both prokaryotes and eukaryotes.