Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice
Liposomal formulation of curcumin attenuates seizures in different experimental models of epilepsy in mice
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DOI：
10.1111/j.1472-8206.2011.01002.x
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发表时间：
2013-04-01
影响因子：
2.9
通讯作者：
Sharma, Krishna K.
中科院分区：
文献类型：
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作者：
Agarwal, Nidhi Bharal;Jain, Seema;Sharma, Krishna K.
现代研究表明姜黄素具有良好的抗惊厥作用。然而，其口服生物利用度差是其药理作用的主要障碍。因此，本研究旨在评估脂质体包埋的姜黄素对小鼠电流电击癫痫发作（ICES）试验、戊四唑（PTZ）诱导的癫痫发作和癫痫持续状态的急性影响。在 ICES 测试和 PTZ 诱导的癫痫发作中，脂质体包埋的姜黄素剂量 25 和 50mg/kg 分别显示癫痫阈值电流和肌阵挛和全身性癫痫发作的潜伏期显着增加。同样，脂质体包埋的姜黄素也增加了小鼠癫痫持续状态期间的发作潜伏期并缩短了癫痫发作的持续时间。总之，脂质体包埋的姜黄素对小鼠癫痫持续状态具有抗惊厥活性。
Contemporary research indicates promising anticonvulsant effect of curcumin. However, its poor oral bioavailability is a major hindrance toward its pharmacological action. Thus, this study was carried out to evaluate the acute effect of liposome-entrapped curcumin on increasing current electroshock seizures (ICES) test, pentylenetetrazole (PTZ)-induced seizures, and status epilepticus in mice. Liposome-entrapped curcumin in doses 25 and 50mg/kg demonstrated significant increase in seizure threshold current and latency to myoclonic and generalized seizures in ICES test and PTZ-induced seizures, respectively. Similarly, liposomal-entrapped curcumin also increased the latency to the onset and decreased the duration of seizures during status epilepticus in mice. To conclude, liposomal-entrapped curcumin possesses anticonvulsant activity against status epilepticus in mice.