Cardiovascular effects of ketanserin in closed-chest anesthetized dogs.
Cardiovascular effects of ketanserin in closed-chest anesthetized dogs.
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酮舍林对闭胸麻醉犬的心血管作用。
DOI：
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发表时间：
1985
影响因子：
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通讯作者：
S. Reneman
中科院分区：
文献类型：
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作者：
A. Van de Water;L. Wouters;R. Xhonneux;S. Reneman
选择性 5 HT2 血清素拮抗剂 Ketanserin（累计剂量为 0.01、0.04、0.16、0.64 和 2.5 mg.kg-1，间隔 30 分钟静脉注射）的心血管作用在闭胸麻醉的心脏自主跳动犬 (n = 7) 和固定心率犬 (n = 7) 中进行了研究。此外，还研究了酮色林 (0.04 mg.kg-1 i.v.) 在血清素输注期间（中位值：20 微克 kg-1.min-1 i.v.）的影响 (n = 7)。酮色林从 0.04 mg.kg-1 开始，通过降低全身血管阻力来降低动脉血压。注射 0.16 mg.kg-1 和更高剂量后心率增加可能本质上是反射性的，继发于全身血管阻力的降低。酮色林还诱导正性肌力作用，从 0.16 mg.kg-1 剂量开始，如心率恒定且左心室舒张末压无变化或略有下降时 LV dP/dt max、LV dP/dt max/P 和最大主动脉血流速度的增加所示。这是否是该化合物的固有特性仍有待进一步研究。除了与左心室功能相关的变量增加外，Ketanserin (0.04 mg.kg-1) 还可阻断 5-羟色胺引起的循环和呼吸变化。对血清素引起的肺动脉高压和支气管收缩的抑制作用尤其显着。酮色林不会阻断血清素的正性肌力特性，这表明胺的这种特性不是 5-HT2 受体介导的。
The cardiovascular effects of the selective 5 HT2-serotonergic antagonist Ketanserin (cumulative doses of 0.01, 0.04, 0.16, 0.64 and 2.5 mg.kg-1 i.v. at 30 min intervals) were investigated in closed-chest, anesthetized dogs with spontaneously beating hearts (n = 7) and in dogs with a fixed heart rate (n = 7). Besides, the effects of Ketanserin (0.04 mg.kg-1 i.v.) during serotonin infusion (median: 20 micrograms kg-1.min-1 i.v.) were studied (n = 7). Ketanserin, starting at 0.04 mg.kg-1, lowers arterial blood pressure through a decrease in systemic vascular resistance. The increase in heart rate after the injection of 0.16 mg.kg-1 and higher doses is likely reflexogenic in nature and secondary to the decrease in systemic vascular resistance. Ketanserin also induces a positive inotropic effect, starting at a dose of 0.16 mg.kg-1 as indicated by the increase in LV dP/dt max, LV dP/dt max/P and maximum aortic blood flow velocity at constant heart rate and in the presence of no change or a slight decrease in left ventricular end-diastolic pressure. Whether this is an intrinsic property of the compound remains subject to further investigation. Except for the increase in the variables related to left ventricular function, Ketanserin (0.04 mg.kg-1) blocks the serotonin induced circulatory and respiratory changes. The inhibition of serotonin induced pulmonary hypertension and bronchoconstriction was especially marked. The positive inotropic properties of serotonin were not blocked by Ketanserin, suggesting that this property of the amine is not 5 HT2-receptor mediated.