The Halogen Bond.
The Halogen Bond.
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DOI：
10.1021/acs.chemrev.5b00484
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发表时间：
2016-02-24
期刊：
影响因子：
62.1
通讯作者：
Terraneo G
中科院分区：
文献类型：
--
作者：
Cavallo G;Metrangolo P;Milani R;Pilati T;Priimagi A;Resnati G;Terraneo G
当有证据表明与分子实体中的卤素原子缔合的亲电子区域与另一个或相同分子实体中的亲核区域之间存在净吸引相互作用时，发生卤键。在这篇相当广泛的综述中，在简要介绍了相互作用的历史之后，我们将为读者提供一个关于卤键研究现状的快照，也许还有它的发展方向。基于使用卤键的设计所带来的特定优势将在从材料科学到生物分子识别和药物设计的不同领域得到证明。
The halogen bond occurs when there is evidence of a net attractive interaction between an electrophilic region associated with a halogen atom in a molecular entity and a nucleophilic region in another, or the same, molecular entity. In this fairly extensive review, after a brief history of the interaction, we will provide the reader with a snapshot of where the research on the halogen bond is now, and, perhaps, where it is going. The specific advantages brought up by a design based on the use of the halogen bond will be demonstrated in quite different fields spanning from material sciences to biomolecular recognition and drug design.