INCREASED PURINE NUCLEOTIDE CYCLE ACTIVITY ASSOCIATED WITH DIETARY ZINC-DEFICIENCY
INCREASED PURINE NUCLEOTIDE CYCLE ACTIVITY ASSOCIATED WITH DIETARY ZINC-DEFICIENCY
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DOI：
10.1016/0006-291x(77)91232-3
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发表时间：
1977-01-01
影响因子：
3.1
通讯作者：
LUECKE, RW
中科院分区：
文献类型：
--
作者：
BRODY, MS;STEINBERG, JR;LUECKE, RW
与限饲锌补充对照组大鼠相比，缺锌断奶大鼠肌肉5“-AMP氨基水解酶（EC 3.5.4.6）、腺苷酸琥珀酸合成酶（EC 6.3.4.4）和腺苷酸琥珀酸裂解酶（EC 4.3.2.2）活性升高50-60%。这些酶的活性增加了50-100%，当锌缺乏大鼠与自由进食对照组相比。3组动物的肌肉总蛋白质或肌肉总锌含量无显著差异。这种嘌呤核苷酸循环活性的增加可能是最近观察到的锌缺乏大鼠血氨增加的原因。
Rat muscle 5''-AMP aminohydrolase (EC 3.5.4.6), adenylosuccinate synthetase (EC 6.3.4.4) and adenylosuccinate lyase (EC 4.3.2.2) activities were elevated 50-60% in Zn-deficient weanling rats when compared with restricted-fed Zn supplemental control rats. The activities of these enzymes were increased by 50-100% when Zn-deficient rats were compared with ad lib fed controls. There was no significant difference in total muscle protein or total muscle Zn among the 3 groups of animals. This increased activity of the purine nucleotide cycle may be responsible for the recently observed increase in blood ammonia in Zn-deficient rats when compared to controls.