Risky Business: Pathways to Progress in Biologically Informed Studies of Psychopathology.
Risky Business: Pathways to Progress in Biologically Informed Studies of Psychopathology.
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DOI：
10.1080/1047840x.2015.1039930
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发表时间：
2015
影响因子：
9.3
通讯作者：
Bogdan R
中科院分区：
文献类型：
--
作者：
Agrawal A;Bogdan R
在目标文章中，Vaidyanathan，Vrieze和Iacono（本期）反映了我们对精神病理学病因学理解的缺乏进展。他们令人信服地认为，理论指导的综合研究，由于其有针对性的测试假定的机制，应优先考虑。通过全面的叙述，并优雅地借鉴了大量的内表型研究，这些作者认为因果理论的“风险测试”（即，缩小因果解释数量的测试）提供了最有可能为我们理解精神病理学提供信息。此外，作者指出，统计数据和技术，如果随意应用，可能会产生危险的后果。相反，他们提倡有风险的研究设计，这些设计由强大的理论基础指导，没有诊断界限，并由多个研究领域的知识推动。我们完全同意他们的建议。
In the target article, Vaidyanathan, Vrieze, and Iacono (this issue) reflect on the lack of advancement in our etiologic understanding of psychopathology. They persuasively argue that theory-guided integrative research, due to its targeted testing of putative mechanisms, should be prioritized. Through a comprehensive narrative, and drawing elegantly on a vast body of endophenotype research, these authors suggest that “risky tests” of causal theories (ie, a test that narrows the number of causal interpretations available) offer the most potential to inform our understanding of psychopathology. In addition, the authors point out that statistics and technology, when haphazardly applied, can have perilous consequences. They advocate instead for risky study designs that are guided by a strong theoretical basis, free of diagnostic boundaries, and fueled by knowledge from multiple research domains. We could not agree more with their proposal.