Three-dimensional imaging of the human retina by high-speed optical coherence tomography
Three-dimensional imaging of the human retina by high-speed optical coherence tomography
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DOI：
10.1364/oe.11.002753
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发表时间：
2003-10-20
期刊：
影响因子：
3.8
通讯作者：
Zhou, QY
中科院分区：
文献类型：
--
作者：
Hitzenberger, CK;Trost, P;Zhou, QY
传统的光学相干层析成像是基于A扫描的，即快速扫描方向是z方向。虽然这项技术已经成功地用于各种组织的二维横断面成像，但如果要获得三维信息，则速度相当慢。我们报告了一种新的技术，它结合了共焦扫描激光检眼镜的横向扫描方法和OCT的深度切片能力。利用声光调制器产生稳定的高频载波，利用谐振扫描镜优先扫描(x方向)获得高帧速率。我们的样机在1.2秒内记录了256x128像素的横向图像，从而提供了迄今为止报道的最快的视网膜3D OCT扫描系统。我们通过在活体内测量和成像健康人类志愿者的中心凹和视神经头部区域来展示我们的系统的能力。(C)2003年美国光学学会。
Conventional optical coherence tomography is based on A-scans, i.e., the fast scan direction is the z-direction. While this technique has been successfully demonstrated for two-dimensional cross sectional imaging of various tissues, it is rather slow if three-dimensional information is to be obtained. We report on a new technique that combines the transverse scanning approach of a confocal scanning laser ophthalmoscope with the depth sectioning capability of OCT. A stable high-frequency carrier is generated by use of an acousto optic modulator, and high frame rate is obtained by using a resonant scanning mirror for the priority scan (x-direction). Our prototype instrument records 64 transverse images consisting of 256x128 pixels in 1.2 seconds, thus providing the fastest retinal 3D OCT scanning system reported so far. We demonstrate the capabilities of our system by measuring and imaging the fovea and the optic nerve head region of healthy human volunteers in vivo. (C) 2003 Optical Society of America.