Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer.
Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer.
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DOI：
10.1002/cncr.27453
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发表时间：
2012-10-01
期刊：
影响因子：
6.2
通讯作者：
Rimm, David L.
中科院分区：
文献类型：
--
作者：
Baquero, Maria T.;Hanna, Jason A.;Neumeister, Veronique;Cheng, Huan;Molinaro, Annette M.;Harris, Lyndsay N.;Rimm, David L.
关键词：
微管相关蛋白（MAPs）内源性调节微管稳定性。为了评估微管稳定性作为一种潜在的生物标志物，我们评估了安定蛋白（一种不稳定蛋白）与MAP-tau（一种稳定蛋白）联合使用的预后价值。使用组织微阵列格式和定量免疫荧光（AQUA）技术测量乳腺癌队列（n = 651）中Stathmin和MAP-tau的表达水平，然后将其与临床和病理特征以及无病生存期相关联。单因素Cox比例风险（PH）模型显示，高稳定素表达预示较差的总生存期（HR = 1.48; 95% CI = 1.119-1.966; P = 0.0061）。生存分析显示，高抑素表达患者的10年生存率为53.1%，低抑素表达患者的10年生存率为67% （log rank， P< 0.003）。Cox多因素分析显示，statismin高表达与年龄、绝经状态、淋巴结状态、核分级、肿瘤大小、ER、PR和HER2表达无关（HR = 1.19; 95% CI= 1.03-1.37; P = 0.01）。MAP-tau与stathmin表达比与无病生存呈正相关（HR = 0.679; 95% CI = 0.517-0.891; P = 0.0053）， MAP-tau与stathmin表达比高的患者10年生存率为65.4%，而MAP-tau与stathmin表达比低的患者10年生存率为52.5% （log rank, P = 0.0009）。Cox多因素分析显示，MAP-tau / stathmin比值是总生存率的独立预测因子（HR = 0.609; 95% CI = 0.422-0.879; P = 0.008）。低安定素和高MAP-tau与乳腺癌微管稳定性增加和预后改善有关。
Microtubule associated proteins (MAPs) endogenously regulate microtubule stability. Here we assess the prognostic value of stathmin, a destabilizing protein in combination with MAP-tau, a stabilizing protein, in order to assess microtubule stabilization as a potential biomarker. Stathmin and MAP-tau expression levels were measured in a breast cancer cohort (n = 651) using the tissue microarray format and quantitative immunofluorescence (AQUA) technology, then correlated with clinical and pathological characteristics and disease free survival. Univariate Cox proportional hazards (PH) models indicated that high stathmin expression predicts worse overall survival (HR = 1.48; 95% CI = 1.119–1.966; P = 0.0061). Survival analysis showed 10-year survival of 53.1% for patients with high stathmin expression versus 67% for low expressers (log rank, P<.003). Cox multivariate analysis showed high stathmin expression was independent of age, menopausal status, nodal status, nuclear grade, tumor size, ER, PR, and HER2 expression (HR = 1.19; 95% CI= 1.03–1.37; P = 0.01). The ratio of MAP-tau to stathmin expression showed a positive correlation to disease free survival (HR = 0.679; 95% CI = 0.517–0.891; P = 0.0053) with a 10-year survival of 65.4% for patients with high MAP-tau to stathmin ratio versus 52.5% survival rate for low ratio (log rank, P = 0.0009). Cox multivariate showed MAP-tau to stathmin ratio was an independent predictor of overall survival (HR = 0.609; 95% CI = 0.422–0.879; P = 0.008). Low stathmin and high MAP-tau are associated with increased microtubule stability and better prognosis in breast cancer.
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DOI：
10.1083/jcb.138.5.1067
发表时间：
1997-09-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Felgner H;Frank R;Biernat J;Mandelkow EM;Mandelkow E;Ludin B;Matus A;Schliwa M
通讯作者：
Schliwa M
影响因子：
3.4
作者：
Choi, M. C.;Raviv, U.;Safinya, C. R.
通讯作者：
Safinya, C. R.
影响因子：
6.2
作者：
Giltnane, Jennifer M.;Moeder, Christopher B.;Rimm, David L.
通讯作者：
Rimm, David L.
影响因子：
4.8
作者：
LARSSON, N;MELANDER, H;GULLBERG, M
通讯作者：
GULLBERG, M
Map2和Tau沿微管原丝的外脊纵向结合。
影响因子：
7.8
作者：
Al-Bassam, Jawdat;Ozer, Rachel S;Safer, Daniel;Halpain, Shelley;Milligan, Ronald A
通讯作者：
Milligan, Ronald A