Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats
Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats
复制标题
DOI：
10.1007/s00213-009-1596-2
复制
发表时间：
2009-10-01
影响因子：
3.4
通讯作者：
Burk, Joshua A.
中科院分区：
文献类型：
--
作者：
Boschen, Karen E.;Fadel, Jim R.;Burk, Joshua A.
食欲素神经元投射到许多大脑区域，包括基底前脑胆碱能神经元。基底前脑皮质胆碱能神经元是正常注意力表现所必需的。因此，食欲素系统可能有助于注意力处理。我们测试了食欲素-1受体的阻断是否会破坏注意力表现。大鼠接受了两阶段持续注意任务的训练，该任务要求对没有信号呈现的实验中的视觉信号（500、100、25毫秒）进行辨别。大鼠在执行任务前全身或基底肌内给予食欲素-1受体拮抗剂SB-334867。全身给药食欲素-1受体拮抗剂SB-334867 （5.0 mg/kg）可降低最长持续时间信号的检测。basbasalis SB-334867 （0.60 μ g）在较长信号持续时间的试验中降低了总体准确性。这些发现表明食欲素有助于注意力处理，尽管基底前脑皮质胆碱能神经元外的神经回路可能介导其中的一些作用。
Orexin neurons project to a number of brain regions, including onto basal forebrain cholinergic neurons. Basal forebrain corticopetal cholinergic neurons are known to be necessary for normal attentional performance. Thus, the orexin system may contribute to attentional processing.We tested whether blockade of orexin-1 receptors would disrupt attentional performance.Rats were trained in a two-lever sustained attention task that required discrimination of a visual signal (500, 100, 25 ms) from trials with no signal presentation. Rats received systemic or intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, prior to task performance.Systemic administration of the orexin-1 receptor antagonist, SB-334867 (5.0 mg/kg), decreased detection of the longest duration signal. Intrabasalis SB-334867 (0.60 mu g) decreased overall accuracy on trials with longer signal durations.These findings suggest that orexins contribute to attentional processing, although neural circuits outside of basal forebrain corticopetal cholinergic neurons may mediate some of these effects.